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High Quality DIAZOXIDE CAS NO 364-98-7 Producer

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  • AZ104
  • Dideu
  • 364-98-7
  • C8H7ClN2O2S
  • 206-668-1
  • China
  • Diazoxide Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

High Quality DIAZOXIDE CAS NO 364-98-7 ProducerProduct_Description_title


Our Reference Specification, for more details, pls contact us for COA, MSDS and certification:

Email & Skype: Service@dideu.com Telephone:+86-29-89586680

Mobile:+86-15129568250; Whatsapp&Wechat: +8615129568250


Specification_title

Item Standard Test Results
Identification A.H-NMR:Comply with the structure Complies
B.LC-MS:Comply with the structure Complies
C.The IR spectrum of sample should be identical with that of reference standard. Complies
D.HPLC-ESI-MS Complies
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
Loss on drying ≤2.0% 0.19%
Heavy metals ≤10 ppm <10ppm
Water ≤1.0% 0.10%
Sulphated ash ≤0.5% determined on 1.0 g. 0.01%
Residue on ignition ≤0.1% 0.03%
Related Substances Unspecified impurities: for each impurity ≤0.10% <0.10%
Total Impurity ≤0.5% 0.18%
Purity ≥99.0% 99.70%
Assay 99.0%~101.0% (anhydrous substance). 99.80%
Storage Preserve in well-closed, light-resistant and airtight containers. Complies






Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

Email & Skype: support@dideu.com  Telephone:+86-29-89586682

Mobile:+86-15129568250; Whatsapp: +8615129568250

Diazoxide Tablets

Action and use

Vasodilator; treatment of hypertension.

Definition

Diazoxide Tablets contain Diazoxide.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of diazoxide, C8H7ClN2O2S

92.5  to 107.5% of the stated amount.

Identification

Shake a quantity of the powdered tablets containing 0.2  g of Diazoxide with 50  ml of absolute ethanol, filter and evaporate the filtrate to dryness at a pressure of 2  kPa. The residue complies with the following tests.


A.  The light absorption, Appendix II B, in the range 230  to 350  nm of a 0.001% w/v solution in 0.1m sodium hydroxide exhibits a maximum only at 280  nm.

B.  Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions.


(1)  0.02% w/v of the residue in methanol.

(2)  0.02% w/v of diazoxide EPCRS in methanol.  


chromatographic conditions

(a)  Use silica gel GF254 as the coating.

(b)  Use the mobile phase as described below. 

(c)  Apply 20 µl of each solution.

(d)  Develop the plate to 15 cm.

(e)  After removal of the plate, dry in air until the solvent has evaporated, examine under ultraviolet light (254  nm) and then treat the plate by Method I and examine again.


mobile phase

20  volumes of acetone, 30  volumes of ether, and 50  volumes of toluene.


confirmation

The principal spot in the chromatogram obtained with solution (1) corresponds in colour and intensity to that in the chromatogram obtained with solution (2).

Tests

Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions.


(1)  Shake a quantity of the powdered tablets containing 0.75  g of Diazoxide with 40  ml of 0.1m sodium hydroxide for 30  minutes, filter and dilute the filtrate to 50  ml with 0.1m sodium hydroxide.

(2)  Dilute 1  volume of solution (1) to 200  volumes with 0.1m sodium hydroxide.


chromatographic conditions

(a)  Use a TLC silica gel GF254 plate.

(b)  Use the mobile phase as described below. 

(c)  Apply 5 µl of each solution.

(d)  Develop the plate to 15 cm.

(e)  After removal of the plate, dry in air and examine under ultraviolet light (254  nm). 


mobile phase

7  volumes of 18m ammonia, 25  volumes of methanol and 68  volumes of chloroform.


limits

Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%).

Assay

Weigh and powder 20  tablets. To a quantity of the powder containing 50  mg of Diazoxide add 70  ml of methanol, shake for 1  hour, add sufficient methanol to produce 100  ml, mix and filter. Dilute 5  ml of the filtrate to 250  ml with 0.1m sodium hydroxide and measure the absorbance of the resulting solution at the maximum at 280  nm, Appendix II B. Calculate the content of C8H7ClN2O2S taking 585 as the value of A(1%, 1  cm) at the maximum at 280  nm.




Packaging&Shipping_title


Our normal packaging is 25kgs/Drum and 200kgs/Drum.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Packaging_title

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Shipping_title

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Payment_Terms_title

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Our_Services_title

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS, BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Our_Services







FAQ_title


Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D) Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.








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