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AZ104
Dideu
364-98-7
C8H7ClN2O2S
206-668-1
China
Diazoxide Tablets
High quality
99.0% Min
99%-101%
Tablet
Solubility in water
1.0% max
0.5% Max
10 ppm Max
H-NMR
0.5% Max
Medicine
High Quality DIAZOXIDE CAS NO 364-98-7 Producer
Our Reference Specification, for more details, pls contact us for COA, MSDS and certification:
Email & Skype: Service@dideu.com Telephone:+86-29-89586680
Mobile:+86-15129568250; Whatsapp&Wechat: +8615129568250
| Item | Standard | Test Results |
| Identification | A.H-NMR:Comply with the structure | Complies |
| B.LC-MS:Comply with the structure | Complies | |
| C.The IR spectrum of sample should be identical with that of reference standard. | Complies | |
| D.HPLC-ESI-MS | Complies | |
| The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | ||
| Loss on drying | ≤2.0% | 0.19% |
| Heavy metals | ≤10 ppm | <10ppm |
| Water | ≤1.0% | 0.10% |
| Sulphated ash | ≤0.5% determined on 1.0 g. | 0.01% |
| Residue on ignition | ≤0.1% | 0.03% |
| Related Substances | Unspecified impurities: for each impurity ≤0.10% | <0.10% |
| Total Impurity ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.70% |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.80% |
| Storage | Preserve in well-closed, light-resistant and airtight containers. | Complies |
Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:
Email & Skype: support@dideu.com Telephone:+86-29-89586682
Mobile:+86-15129568250; Whatsapp: +8615129568250
Diazoxide Tablets | |
| Action and use | Vasodilator; treatment of hypertension. |
Definition | Diazoxide Tablets contain Diazoxide. The tablets comply with the requirements stated under Tablets and with the following requirements. |
Content of diazoxide, C8H7ClN2O2S | 92.5 to 107.5% of the stated amount. |
| Identification | Shake a quantity of the powdered tablets containing 0.2 g of Diazoxide with 50 ml of absolute ethanol, filter and evaporate the filtrate to dryness at a pressure of 2 kPa. The residue complies with the following tests. A. The light absorption, Appendix II B, in the range 230 to 350 nm of a 0.001% w/v solution in 0.1m sodium hydroxide exhibits a maximum only at 280 nm. B. Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions. (1) 0.02% w/v of the residue in methanol. (2) 0.02% w/v of diazoxide EPCRS in methanol. chromatographic conditions (a) Use silica gel GF254 as the coating. (b) Use the mobile phase as described below. (c) Apply 20 µl of each solution. (d) Develop the plate to 15 cm. (e) After removal of the plate, dry in air until the solvent has evaporated, examine under ultraviolet light (254 nm) and then treat the plate by Method I and examine again. mobile phase 20 volumes of acetone, 30 volumes of ether, and 50 volumes of toluene. confirmation The principal spot in the chromatogram obtained with solution (1) corresponds in colour and intensity to that in the chromatogram obtained with solution (2). |
Tests
Related substances | Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions. (1) Shake a quantity of the powdered tablets containing 0.75 g of Diazoxide with 40 ml of 0.1m sodium hydroxide for 30 minutes, filter and dilute the filtrate to 50 ml with 0.1m sodium hydroxide. (2) Dilute 1 volume of solution (1) to 200 volumes with 0.1m sodium hydroxide. chromatographic conditions (a) Use a TLC silica gel GF254 plate. (b) Use the mobile phase as described below. (c) Apply 5 µl of each solution. (d) Develop the plate to 15 cm. (e) After removal of the plate, dry in air and examine under ultraviolet light (254 nm). mobile phase 7 volumes of 18m ammonia, 25 volumes of methanol and 68 volumes of chloroform. limits Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%). |
| Assay | Weigh and powder 20 tablets. To a quantity of the powder containing 50 mg of Diazoxide add 70 ml of methanol, shake for 1 hour, add sufficient methanol to produce 100 ml, mix and filter. Dilute 5 ml of the filtrate to 250 ml with 0.1m sodium hydroxide and measure the absorbance of the resulting solution at the maximum at 280 nm, Appendix II B. Calculate the content of C8H7ClN2O2S taking 585 as the value of A(1%, 1 cm) at the maximum at 280 nm. |
High Quality DIAZOXIDE CAS NO 364-98-7 Producer
Our Reference Specification, for more details, pls contact us for COA, MSDS and certification:
Email & Skype: Service@dideu.com Telephone:+86-29-89586680
Mobile:+86-15129568250; Whatsapp&Wechat: +8615129568250
| Item | Standard | Test Results |
| Identification | A.H-NMR:Comply with the structure | Complies |
| B.LC-MS:Comply with the structure | Complies | |
| C.The IR spectrum of sample should be identical with that of reference standard. | Complies | |
| D.HPLC-ESI-MS | Complies | |
| The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | ||
| Loss on drying | ≤2.0% | 0.19% |
| Heavy metals | ≤10 ppm | <10ppm |
| Water | ≤1.0% | 0.10% |
| Sulphated ash | ≤0.5% determined on 1.0 g. | 0.01% |
| Residue on ignition | ≤0.1% | 0.03% |
| Related Substances | Unspecified impurities: for each impurity ≤0.10% | <0.10% |
| Total Impurity ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.70% |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.80% |
| Storage | Preserve in well-closed, light-resistant and airtight containers. | Complies |
Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:
Email & Skype: support@dideu.com Telephone:+86-29-89586682
Mobile:+86-15129568250; Whatsapp: +8615129568250
Diazoxide Tablets | |
| Action and use | Vasodilator; treatment of hypertension. |
Definition | Diazoxide Tablets contain Diazoxide. The tablets comply with the requirements stated under Tablets and with the following requirements. |
Content of diazoxide, C8H7ClN2O2S | 92.5 to 107.5% of the stated amount. |
| Identification | Shake a quantity of the powdered tablets containing 0.2 g of Diazoxide with 50 ml of absolute ethanol, filter and evaporate the filtrate to dryness at a pressure of 2 kPa. The residue complies with the following tests. A. The light absorption, Appendix II B, in the range 230 to 350 nm of a 0.001% w/v solution in 0.1m sodium hydroxide exhibits a maximum only at 280 nm. B. Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions. (1) 0.02% w/v of the residue in methanol. (2) 0.02% w/v of diazoxide EPCRS in methanol. chromatographic conditions (a) Use silica gel GF254 as the coating. (b) Use the mobile phase as described below. (c) Apply 20 µl of each solution. (d) Develop the plate to 15 cm. (e) After removal of the plate, dry in air until the solvent has evaporated, examine under ultraviolet light (254 nm) and then treat the plate by Method I and examine again. mobile phase 20 volumes of acetone, 30 volumes of ether, and 50 volumes of toluene. confirmation The principal spot in the chromatogram obtained with solution (1) corresponds in colour and intensity to that in the chromatogram obtained with solution (2). |
Tests
Related substances | Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions. (1) Shake a quantity of the powdered tablets containing 0.75 g of Diazoxide with 40 ml of 0.1m sodium hydroxide for 30 minutes, filter and dilute the filtrate to 50 ml with 0.1m sodium hydroxide. (2) Dilute 1 volume of solution (1) to 200 volumes with 0.1m sodium hydroxide. chromatographic conditions (a) Use a TLC silica gel GF254 plate. (b) Use the mobile phase as described below. (c) Apply 5 µl of each solution. (d) Develop the plate to 15 cm. (e) After removal of the plate, dry in air and examine under ultraviolet light (254 nm). mobile phase 7 volumes of 18m ammonia, 25 volumes of methanol and 68 volumes of chloroform. limits Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%). |
| Assay | Weigh and powder 20 tablets. To a quantity of the powder containing 50 mg of Diazoxide add 70 ml of methanol, shake for 1 hour, add sufficient methanol to produce 100 ml, mix and filter. Dilute 5 ml of the filtrate to 250 ml with 0.1m sodium hydroxide and measure the absorbance of the resulting solution at the maximum at 280 nm, Appendix II B. Calculate the content of C8H7ClN2O2S taking 585 as the value of A(1%, 1 cm) at the maximum at 280 nm. |
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