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High Quality USP/EP/BP GMP DMF FDA Aciclovir Oral Suspension CAS NO 59277-89-3 Producer

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Price: $ 0.08 / pcs
Quantity:
min order: 1 pcs
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ554
  • Dideu
  • 59277-89-3
  • C8H11N5O3
  • 261-685-1
  • China
  • Oral Suspension
  • High quality
  • 99.0% Min
  • 99%-101%
  • Oral Suspension
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Aciclovir Oral Suspension 

Action and use

Purine nucleoside analogue; antiviral (herpesviruses).

Definition

Aciclovir Oral Suspension is a suspension of Aciclovir in a suitable flavoured vehicle.

The oral suspension complies with the requirements stated under Oral Liquids and with the following requirements.

Content of aciclovir, C8H11N5O3

95.0  to 105.0% of the stated amount.

Identification

A.  The light absorption, Appendix II B, in the range 230  to 250  nm of the solution prepared in the Assay before the final dilution exhibits a maximum at 255  nm and a broad shoulder at about 274  nm.


B.  In the test for Guanine, the principal spot in the chromatogram obtained with solution (2) is similar in position and intensity to that in the chromatogram obtained with solution (3). If the Rf values of the principal spots in the chromatograms obtained with solutions (2) and (3) are different, the oral suspension complies if the chromatogram obtained with solution (5) shows a single, compact spot.

Tests

Related substances

Acidity

pH, 4.0  to 7.0, Appendix V L.

Guanine

Carry out the test described under Aciclovir Intravenous Infusion but applying 5 µl of each of the following solutions. For solution (1) add 20  ml of 0.1m sodium hydroxide to a quantity of the oral suspension containing 0.6  g of Aciclovir, shake to disperse and add sufficient absolute ethanol to produce 100  ml. Mix well and allow any suspended material to settle before application to the plate. For solution (2) dilute 1  volume of solution (1) to 10  volumes with a mixture of 35  volumes of 0.1m sodium hydroxide and 65  volumes of absolute ethanol. For solution (3) dissolve 6  mg of aciclovir BPCRS in 10  ml of a mixture of 35  volumes of 0.1m sodium hydroxide and 65  volumes of absolute ethanol. For solution (4) dissolve 6  mg of guanine in 100  ml of a mixture of 35  volumes of 0.1m sodium hydroxide and 65  volumes of absolute ethanol (1%). Solution (5) contains equal volumes of solutions (2) and (3).

AssayTo a weighed quantity containing 0.4  g of Aciclovir add 400  ml of water and 25  ml of 1m sulphuric acid, shake well, disperse with the aid of ultrasound for 10  minutes and add sufficient water to produce 500  ml. Filter the resulting solution, discard the first few ml of filtrate and dilute 5  ml of the filtrate to 200  ml with 0.05m sulphuric acid. Add 10  ml of the resulting solution to 5  ml of a 0.01% w/v solution of cetrimide in 0.05m sulphuric acid, add sufficient 0.05m sulphuric acid to produce 100  ml and measure the fluorescence, Appendix II E, using an excitation wavelength of 308  nm and an emission wavelength of 415  nm. Set the instrument to zero using a 0.0005% w/v solution of cetrimide in 0.05m sulphuric acid. Calculate the content of C8H11N5O3 in the oral suspension from the fluorescence obtained by carrying out the operation at the same time using a mixture prepared by adding 10  ml of a 0.002% w/v solution of aciclovir BPCRS in 0.05m sulphuric acid and beginning at the words 'to 5  ml of a 0.01% w/v solution of cetrimide ...'. Determine the weight per ml of the oral suspension, Appendix V G, and calculate the content of C8H11N5O3, weight in volume, using the declared content of C8H11N5O3 in aciclovir BPCRS.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Oral Suspension 1Oral Suspension 15Oral Suspension 46

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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