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Purine nucleoside analogue; antiviral (herpesviruses).
Aciclovir Tablets contain Aciclovir.
The tablets comply with the requirements stated under Tablets and with the following requirements.
Content of aciclovir, C8H11N5O3
95.0 to 105.0% of the stated amount.
A. The light absorption, Appendix II B, in the range 230 to 350 nm of the solution prepared in the Assay exhibits a maximum at 255 nm and a broad shoulder at about 274 nm.
B. In the test for Guanine, the principal spot in the chromatogram obtained with solution (2) is similar in position and intensity to that in the chromatogram obtained with solution (3).
Comply with the test described under Aciclovir Intravenous Infusion but preparing solution (1) in the following manner. Shake a quantity of the powdered tablets containing 0.25 g of Aciclovir with 25 ml of 0.1m sodium hydroxide for 10 minutes. Add a sufficient quantity of 0.1m sodium hydroxide to produce 50 ml, allow to stand and allow any undissolved material to settle before application to the plate.
Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900 ml of 0.1m hydrochloric acid and rotate the paddle at 50 revolutions per minute. Withdraw a sample of 25 ml of the medium and filter. Measure the absorbance of the filtered solution, diluted if necessary with 0.1m hydrochloric acid, at the maximum at 255 nm, Appendix II B. Calculate the total content of aciclovir, C8H11N5O3, in the medium taking 560 as the value of A (1%, 1 cm) at the maximum at 255 nm.
Carry out the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of 2 volumes of 13.5m ammonia, 20 volumes of methanol and 80 volumes of dichloromethane as the mobile phase but allowing the solvent front to ascend 10 cm above the line of application. Apply separately to the plate 2 µl of each of the following freshly prepared solutions. For solution (1) shake a quantity of the powdered tablets containing 0.25 g of Aciclovir with 10 ml of dimethyl sulphoxide for 15 minutes and filter. For solution (2) dilute 0.7 volumes of solution (1) to 100 volumes with dimethyl sulphoxide. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254 nm). In the chromatogram obtained with solution (1) any secondary spot with an Rf value greater than that of the principal spot is not more intense than the spot in the chromatogram obtained with solution (2) (0.7%).
Weigh and finely powder 20 tablets. To a quantity of the powdered tablets containing 0.1 g of Aciclovir add 60 ml of 0.1m sodium hydroxide and disperse with the aid of ultrasound for 15 minutes. Add a sufficient quantity of 0.1m sodium hydroxide to produce 100 ml, mix well and filter. To 15 ml of the filtrate add 50 ml of water and 5.8 ml of 2m hydrochloric acid and sufficient water to produce 100 ml. To 5 ml of the solution add sufficient 0.1m hydrochloric acid to produce 50 ml and mix well. Measure the absorbance of the resulting solution at the maximum at 255 nm, Appendix II B, using 0.1m hydrochloric acid in the reference cell. Calculate the content of C8H11N5O3 taking 560 as the value of A (1%, 1 cm) at the maximum at 255 nm.
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a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.