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|Action and use|
Histamine H1 receptor antagonist; antihistamine.
Alimemazine Tablets contain Alimemazine Tartrate.
The tablets comply with the requirements stated under Tablets and with the following requirements.
Content of alimemazine tartrate, C36H44N4S2,C4H6O6
92.5 to 107.5% of the stated amount.
A. To a quantity of the powdered tablets containing 40 mg of Alimemazine Tartrate add 10 ml of water and 2 ml of 1m sodium hydroxide, shake and extract with 15 ml of ether. Wash the ether layer with 5 ml of water, dry with anhydrous sodium sulphate and evaporate the ether to dryness. Dissolve the residue in 0.4 ml of dichloromethane. The infrared absorption spectrum of the resulting solution, Appendix II A, is concordant with the reference spectrum of alimemazine (RS 005).
B. To a quantity of the powdered tablets containing 1 mg of Alimemazine Tartrate add 1 ml of a mixture of equal volumes of formaldehyde solution and sulphuric acid. A purple colour is produced.
Tests Related substances
Comply with the test for related substances in phenothiazines, Appendix III A, using mobile phase A and applying separately to the plate 20 µl of each of the following freshly prepared solutions. For solution (1) extract a quantity of the powdered tablets containing 0.1 g of Alimemazine Tartrate with 10 ml of a mixture of 95 volumes of methanol and 5 volumes of diethylamine and filter. For solution (2) dilute 1 volume of solution (1) to 200 volumes with the same solvent mixture.
Carry out the following procedure protected from light. Add 150 ml of 0.1m hydrochloric acid to 10 tablets, shake for 10 minutes, mix with the aid of ultrasound for 1 minute, dilute with 0.1m hydrochloric acid to produce a solution containing 0.050% w/v of Alimemazine Tartrate and filter (solution A). Dilute 10 ml of solution A to 100 ml with water (solution B). To a further 10 ml of solution A add 2 ml of peroxyacetic acid solution, mix, allow to stand for 5 minutes and add sufficient water to produce 100 ml (solution C). Measure the absorbance of solution C at the maximum at 342 nm, Appendix II B, using solution B in the reference cell and measure the absorbance of solution B at the same wavelength using water in the reference cell. Repeat the procedure using a 0.05% w/v solution of alimemazine tartrate BPCRS in 0.1m hydrochloric acid in place of solution A, beginning at the words 'Dilute 10 ml of solution A ...' and calculate the content of C36H44N4S2,C4H6O using the declared content of C36H44N4S2,C4H6O in alimemazine tartrate BPCRS. The test is not valid if the absorbance of solution B is more than 0.10.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.
a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.