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High Quality USP/EP/BP GMP DMF FDA Alpha Tocopheryl Succinate Tablets CAS NO Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ009
  • Dideu
  • China
  • Alpha Tocopheryl Succinate Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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                                                                                Alpha Tocopheryl Succinate Tablets

Definition

Alpha Tocopheryl Succinate Tablets contain RRR-Alpha-Tocopheryl Hydrogen Succinate. They are coated.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of α-tocopherol, C29H50O2

95.0  to 105.0% of the stated amount.





Identification

A.  Carry out the method for thin-layer chromatography, Appendix III A, using silica gel HF254 as the coating substance and a mixture of 20  volumes of ether and 80  volumes of cyclohexane as the mobile phase. Apply separately to the plate 10 µl of each of the following solutions. For solution (1) shake a quantity of the powdered tablets containing the equivalent of 0.134  g of α-tocopherol with three 10  ml quantities of ether, filter, evaporate the combined filtrates to 2  ml and then evaporate the solution to dryness under a current of nitrogen. Prepare a 0.5% w/v solution from a portion of the resulting residue in cyclohexane. For solution (2) dissolve 10  mg of the residue obtained in the preparation of solution (1) in 2  ml of 5m ethanolic sulphuric acid, heat in a water bath for 1  minute, cool, add 2  ml each of water and cyclohexane and shake for 1  minute; use the upper layer. Solution (3) contains 0.5% w/v of RRR-α-tocopheryl succinate EPCRS in cyclohexane. Prepare solution (4) in the same manner as solution (2) but using 10  mg of RRR-α-tocopheryl succinate EPCRS in place of the substance being examined.


After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). The principal spot in the chromatogram obtained with solution (1) is similar in position and size to that in the chromatogram obtained with solution (3). There are two spots in each of the chromato-grams obtained with solutions (2) and (4). Spray the plate with a mixture of 1  volume of hydrochloric acid, 4  volumes of a 0.25% w/v solution of iron (III) chloride hexahydrate in ethanol (96%) and 4  volumes of a 1% w/v solution of 1,10-phenanthroline hydrochloride in ethanol (96%). In the chromatograms obtained with solutions (2) and (4) the spot of higher Rf value, due to α-tocopherol, is orange.


B.  In the Assay the principal peak in the chromatogram obtained with solution (1) shows a peak with the same retention time as the peak due to the methylated alpha tocopheryl succinate in the chromatogram obtained with solution (2).






Tests

Free tocopherol

Carry out the method for thin-layer chromatography, Appendix III A, using silica gel HF254 as the coating substance and a mixture of 20  volumes of ether and 80  volumes of cyclohexane as the mobile phase. Apply separately to the plate 10 µl of each of the following solutions. For solution (1) shake a quantity of the powdered tablets containing the equivalent of 134  mg of α-tocopherol with three 10  ml quantities of ether, filter and evaporate the combined filtrates to 2  ml, evaporate the final solution to dryness under a current of nitrogen and prepare a 0.5% w/v solution from the resulting residue in cyclohexane. Solution (2) contains 0.005% w/v of α-tocopherol EPCRS in cyclohexane. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the principal spot in the chromatogram obtained with solution (2) (1%).

Assay

Carry out the method for gas chromatography, Appendix III B, using the following solutions. Dissolve 0.15  g of dotriacontane (internal standard) in sufficient hexane to produce 100  ml (solution A). For solution (1) mix a quantity of the powdered tablets containing the equivalent of 134  mg of α-tocopherol with 20  ml of methanol, mix with the aid of ultrasound for 5  minutes and centrifuge for 15  minutes. To 4  ml of the clear supernatant liquid add 2  ml of 2,2-dimethoxypropane and 0.2  ml of hydrochloric acid and allow to stand in the dark at room temperature for 1  hour. Evaporate to dryness on a water bath with the aid of a current of nitrogen and dissolve the residue in 10  ml of solution A. For solution (2) dissolve 0.165  g of RRR-α-tocopheryl succinate EPCRS in 20  ml of methanol and continue in the same manner as solution (1) using 4  ml and beginning at the words 'add 2  ml of 2,2-dimethoxy-propane...'.


The chromatographic procedure may be carried out using a borosilicate glass column (2 m × 4  mm) packed with acid-washed, silanised diatomaceous support (100  to 120  mesh) (Chromosorb W/AW is suitable) coated with 2  to 5% of polymethylsiloxane. Set the temperature of the column and the rate of flow of carrier gas at values such that the required resolution is achieved (a column temperature of 280° and a rate of flow of carrier gas of 40  ml per minute are suitable). Maintain the temperature of the injection port at 290° and the detector at 350°. The retention times of dotriacontane and methyl α-tocopheryl succinate (obtained in solution (1)) are about 8  minutes and 20  minutes, respectively.


Calculate the content of C29H50O2 from the areas of the peaks due to dotriacontane and methyl α-tocopheryl succinate in the chromatograms obtained with solution (1) and solution (2) and from the declared content of C29H50O2 in RRR-α-tocopheryl succinate EPCRS.

Storage

Alpha Tocopheryl Succinate Tablets should be protected from light.

LabellingThe quantity of active ingredient is stated in terms of the equivalent amount of α-tocopherol.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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