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High Quality USP/EP/BP GMP DMF FDA Atenolol Tablets CAS NO 29122-68-7 Producer

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Price: $ 0.08 / Tablet
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  • AZ019
  • Dideu
  • 29122-68-7
  • C14H22N2O3
  • 249-451-7
  • China
  • Atenolol Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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                                                                              Atenolol Tablets

Action and use

Beta-adrenoceptor antagonist.


Atenolol Tablets contain Atenolol.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of atenolol, C14H22N2O392.5  to 107.5% of the stated amount.


A.  Heat a quantity of the powdered tablets containing 0.1  g of Atenolol with 15  ml of methanol to 50°, shake for 5  minutes, filter (Whatman No. 42 paper is suitable) and evaporate the filtrate to dryness on a water bath. Warm the residue with 10  ml of 0.1m hydrochloric acid, shake and filter. Add to the filtrate sufficient 1m sodium hydroxide to make it alkaline, extract with 10  ml of chloroform, dry by shaking with anhydrous sodium sulphate, filter, evaporate the filtrate to dryness on a water bath and dry the residue at 105° for 1  hour. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of atenolol (RS 015).

B.  The light absorption, Appendix II B, in the range 230  to 350  nm of the solution obtained in the Assay exhibits maxima at 275  nm and 282  nm.


Related substances

Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) shake a quantity of the powdered tablets containing 25  mg of Atenolol with 25  ml of the mobile phase, mix with the aid of ultrasound for 20  minutes, filter (Whatman GF/C filter paper is suitable) and use the filtrate. For solution (2) dilute 1  volume of solution (1) to 200  volumes with the mobile phase. For solution (3) dissolve 10  mg of atenolol impurity standard BPCRS in 0.1  ml of dimethyl sulphoxide, with the aid of gentle heat, add 10  ml of the mobile phase and mix.

The chromatographic procedure may be carried out using (a) a stainless steel column (15  cm × 4.6  mm) packed with end-capped octadecylsilyl silica gel for chromatography (5 µm) (Spherisorb ODS 2 is suitable), (b) as the mobile phase with a flow rate of 1  ml per minute a mixture prepared as described below and (c) a detection wavelength of 226  nm. For the mobile phase dissolve 0.8  g of sodium octanesulphonate and 0.4  g of tetrabutylammonium hydrogen sulphate in 1  litre of a mixture of 20  volumes of tetrahydrofuran, 180  volumes of methanol and 800  volumes of a 0.34% w/v solution of potassium dihydrogen orthophosphate; adjust the pH to 3.0 with orthophosphoric acid. Inject 20 µl of each solution.

The test is not valid unless the chromatogram obtained with solution (3) resembles the reference chromatogram provided with atenolol impurity standard BPCRS in that the peak due to bis ether precedes, and is separated from, that due to tertiary amine, which is normally a doublet. If necessary, adjust the concentration of sodium octanesulphonate in the mobile phase; increasing the concentration increases the retention time of the tertiary amine.

In the chromatogram obtained with solution (1) the area of any peak corresponding to blocker acid is not greater than the area of the peak in the chromatogram obtained with solution (2) (0.5%) and the area of any peak corresponding to either tertiary amine or bis ether is not greater than half of the area of the peak in the chromatogram obtained with solution (2) (0.25%).


owder 20  tablets. Transfer the powder to a 500  ml flask using 300  ml of methanol, heat the resulting suspension to 60° and shake for 15  minutes. Cool, dilute to 500  ml with methanol, filter through a fine glass micro-fibre filter paper (Whatman GF/C is suitable) and dilute a suitable volume of the filtrate with sufficient methanol to produce a solution containing 0.01% w/v of Atenolol. Measure the absorbance of the resulting solution at the maximum at 275  nm, Appendix II B. Calculate the content of C14H22N2O3  taking 53.7 as the value of A(1%, 1  cm) at the maximum at 275  nm.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

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Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

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V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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