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High Quality USP/EP/BP GMP DMF FDA Calcium Gluconate Tablets CAS NO 299-28-5 Producer

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  • AZ039
  • Dideu
  • 299-28-5
  • C12H22CaO14
  • 206-075-8
  • China
  • Calcium Gluconate Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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                                                                                 Calcium Gluconate Tablets 

Definition

Calcium Gluconate Tablets contain Calcium Gluconate. Tablets that are intended to be chewed before swallowing are prepared using Chocolate Basis or other suitable basis with a chocolate flavour.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of calcium gluconate, C12H22CaO14,H2O


95.0  to 105.0% of the stated amount.

Identification

A.  Extract five tablets, finely powdered, with two 25-ml quantities of petroleum spirit (boiling range, 40° to 60°), discard the extracts and repeat the extraction with three 10  ml quantities of water, again discarding the extracts. Dissolve the residue as completely as possible in 30  ml of hot water, filter and to 0.5  ml of the filtrate add 0.05  ml of iron(iii) chloride solution R1. An intense yellow colour is produced.

B.  To a volume of the filtrate obtained in test A containing 0.5  g of Calcium Gluconate add 0.65  ml of glacial acetic acid and 1  ml of phenylhydrazine, heat on a water bath for 30  minutes, cool and induce crystallisation. Filter, dissolve the residue in 10  ml of hot water, add a few mg of activated charcoal, shake, filter, allow the filtrate to cool and induce crystallisation. A white, crystalline precipitate is produced. The melting point of the crystals, after drying, is about 201°, with decomposition, Appendix V A.

C.  The powdered tablets yield the reactions characteristic of calcium salts, Appendix VI.



Tests

Related substances

Disintegration

The requirement for Disintegration does not apply to Calcium Gluconate Tablets.


Dissolution

Tablets intended to be swallowed whole comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900  ml of water and rotate the paddle at 50 revolutions per minute. Withdraw a sample of 20  ml of the medium and filter. Carry out the method for atomic absorption spectrophotometry, Appendix II D, measuring at 422.7  nm using a calcium hollow-cathode lamp as the radiation source, an air-acetylene flame and the following solutions.


Test solution  Use the filtered dissolution medium diluted, if necessary, with water to give a concentration suitable for the instrument used.


Standard solutions  Use calcium standard solution (100  ppm Ca) suitably diluted with water.


Determine the total content of calcium in the dissolution medium and calculate the content of calcium gluconate taking each mg of calcium to be equivalent to 11.21  mg of C12H22CaO14,H2O.

Assay

Weigh and powder 20  tablets. Ignite a quantity of the powder containing 0.5  g of Calcium Gluconate, cool and dissolve the residue with gentle heat in 5  ml of 2m hydrochloric acid. Filter, wash the residue on the filter with water and dilute the combined filtrate and washings to 50  ml with water. Neutralise with 5m ammonia, using methyl orange solution as indicator, add 5  ml of 8m sodium hydroxide and titrate with 0.05m disodium edetate VS using calconcarboxylic acid triturate as indicator. Each ml of 0.05m disodium edetate VS is equivalent to 22.42  mg of C12H22CaO14,H2O.

Labelling


The label states, where appropriate, that the tablets should be chewed before swallowing.

When Calcium Gluconate Tablets are prescribed or demanded, no strength being stated, tablets containing 600  mg shall be dispensed or supplied.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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