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Urea Cream contains Urea in a suitable basis.
The cream complies with the requirements stated under Topical Semi-solid Preparations and with the following requirements.
Content of urea, CH4N2O
90.0 to 110.0% of the stated amount.
A. Carry out the method for thin-layer chromatography, Appendix III A, using a silica gel precoated plate (Merck silica gel 60 plates are suitable). Apply separately to the plate 10 µl of each of the following solutions. For solution (1) disperse with heating a quantity of the cream containing 50 mg of Urea in 1 ml of water, cool, add 4 ml of acetone, mix and filter. For solution (2) dissolve 50 mg of urea in 1 ml of water and add 4 ml of acetone. Solution (3) is a mixture of equal volumes of solutions (1) and (2). For the first development use 2,2,4-trimethylpentane as the mobile phase. Remove the plate and allow it to dry in air. For the second development use as the mobile phase a mixture of 99 volumes of absolute ethanol and 1 volume of 13.5m ammonia. After removal of the plate, allow it to dry in air and spray with a solution containing 0.5% w/v of 4-dimethylaminobenzaldehyde and 0.5% v/v of sulphuric acid in absolute ethanol. The principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2). The test is not valid unless the chromatogram obtained with solution (3) shows a single, compact principal spot.
B. To a quantity containing 0.1 g of Urea add 50 ml of water and heat until dispersed, cool in ice and filter through glass wool. Adjust the pH of the filtrate, which may not be clear, to between 6.0 and 7.0 using 0.1m hydrochloric acid or 0.1m sodium hydroxide as necessary. To 5 ml add 5 ml of a 0.1% w/v suspension of urease-active meal and allow to stand for 30 minutes in a stoppered flask at 37°. When the resulting solution is heated in a water bath, a vapour is produced that turns moist red litmus paper blue.
Not more than 2.0% with respect to the content of urea, CH4N2O (determined in the Assay) when determined by the following method. Prepare a 0.035% w/v solution of ammonium sulphate in 1m sulphuric acid (solution A). Carry out the method for ion-selective potentiometry, Appendix VIII E, using an ammonia-selective electrode. Determine the response slope of the electrode using standard ammonia solutions and measure the emf in the following solutions. For solution (1) shake a quantity of the cream (w1 g) containing 40 mg of Urea with 5 ml of 1m sulphuric acid to disperse, warming if necessary, add 10 ml of 2,2,4-trimethylpentane, shake for 2 minutes and centrifuge. Dilute 3 ml of the aqueous layer to 50 ml with water and to 20 ml of the resulting solution add 4 ml of 1m sodium hydroxide. Prepare solution (2) in the same manner but shaking a quantity of the cream (w2 g) containing 40 mg of Urea with 5 ml of solution A in place of 5 ml of 1m sulphuric acid.
Calculate C1 and hence the concentration of ammonia in the cream from the expression:
ΔE = a log(w2/w1 + C2/C1)
ΔE = the difference in the emf, in mV, obtained with the two solutions,
a = the response slope in mV per decade,
C1 = the concentration of ammonia in solution (1) as % w/v,
C2 = the concentration of standard added ammonia in solution (2) as % w/v (this is 0.0129 times the concentration of ammonium sulphate in solution A as % w/v), namely 0.000451% w/v.
Shake a quantity containing 42 mg of Urea with 150 ml of hot water for 20 minutes, allow to cool and dilute to 500 ml with water. Filter through a fine glass microfibre filter paper (Whatman GF/C is suitable), transfer 1 ml of the filtrate to a 100 ml graduated flask, add 2 ml of a 0.1% w/v suspension of urease-active meal, stopper the flask and allow to stand for 15 minutes at 37°. Immediately add 25 ml of a solution containing 12 g of sodium salicylate and 0.24 g of sodium nitroprusside in 200 ml and 25 ml of a solution prepared by diluting a volume of sodium hypochlorite solution containing the equivalent of 0.66 g of available chlorine with 0.2m sodium hydroxide to 1000 ml. Mix well, allow to stand at 37° for 5 minutes and dilute to 100 ml with water. Measure the absorbance of the resulting solution at the maximum at 665 nm, Appendix II B, using in the reference cell a solution prepared in the same manner but using 1 ml of water in place of 1 ml of the filtrate. Repeat the operation using 42 mg of urea BPCRS in place of the cream being examined. Calculate the content of CH4N2O from the absorbances obtained using the declared content of CH4N2O in urea BPCRS.
Urea Cream should be stored in accordance with the manufacturer's instructions.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.
a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.