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Chlordiazepoxide Hydrochloride Tablets
|Action and use|
Chlordiazepoxide Hydrochloride Tablets contain Chlordiazepoxide Hydrochloride.
The tablets comply with the requirements stated under Tablets and with the following requirements.
Content of chlordiazepoxide, C16H14ClN3O
90.0 to 110.0% of the stated amount.
A. Dilute 1 volume of the final solution obtained in the Assay to 2 volumes with 0.1m hydrochloric acid. The light absorption, Appendix II B, in the range 230 to 350 nm exhibits two maxima, at 246 nm and 308 nm.
B. To a quantity of the powdered tablets containing the equivalent of 0.2 g of chlordiazepoxide add 4 ml of hot 2m hydrochloric acid, heat at 100° for 10 minutes, cool and filter. 2 ml of the filtrate yields the reaction characteristic of primary aromatic amines, Appendix VI, producing a reddish precipitate.
C. Shake a quantity of the powdered tablets containing the equivalent of 25 mg of chlordiazepoxide with 2.5 ml of water, add 0.5 ml of 6m ammonia, mix, allow to stand for 5 minutes and filter. The filtrate, after making acidic with 2m nitric acid, yields reaction A characteristic of chlorides, Appendix VI.
Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of 85 volumes of chloroform, 14 volumes of methanol and 1 volume of 13.5m ammonia as the mobile phase. Prepare the following solutions immediately before use in acetone containing 2% v/v of 13.5m ammonia and 8% v/v of water. For solution (1) shake a quantity of the powdered tablets containing the equivalent of 0.10 g of chlordiazepoxide with 10 ml of the solvent mixture, allow to settle and use the supernatant liquid. For solution (2) dilute 5 volumes of solution (1) to 100 volumes with the same solvent mixture. For solution (3) dilute 1 volume of solution (1) to 100 volumes with the same solvent. Solution (4) contains 0.01% w/v of 2-amino-5-chlorobenzophenone. Apply separately to the plate 2-µl and 20-µl quantities of solution (1), 2 µl of each of solutions (2) and (3) and 20 µl of solution (4). After removal of the plate, allow it to dry in air and examine under ultraviolet light (254 nm). Any secondary spot in the chromatogram obtained with 2 µl of solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (5%) and not more than one such spot is more intense than the spot in the chromatogram obtained with solution (3) (1%). Spray the plate with a freshly prepared 1% w/v solution of sodium nitrite in 1m hydrochloric acid, dry it in a current of cold air and spray with a 0.4% w/v solution of N-(1-naphthyl)ethylenediamine dihydrochloride in ethanol (96%). Any violet spot corresponding to 2-amino-5-chlorobenzophenone in the chromatogram obtained with 20 µl of solution (1) is not more intense than the spot in the chromatogram obtained with solution (4) (1%).
Shake 10 whole tablets with 150 ml of 0.1m hydrochloric acid for 20 minutes, add sufficient 0.1m hydrochloric acid to produce 250 ml and filter. Dilute 10 ml of the filtrate with sufficient 0.1m hydrochloric acid to produce a solution containing the equivalent of 0.0020% w/v of chlordiazepoxide and measure the absorbance of the resulting solution at the maximum at 308 nm, Appendix II B. Calculate the content of C16H14ClN3O taking 327 as the value of A(1%, 1 cm) at the maximum at 308 nm.
The quantity of active ingredient is stated in terms of the equivalent amount of chlordiazepoxide.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.
a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.