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High Quality USP/EP/BP GMP DMF FDA Chlortalidone Tablets CAS NO 77-36-1 Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ058
  • Dideu
  • 77-36-1
  • C14H11ClN2O4S
  • 201-022-5
  • China
  • Chlortalidone Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Chlortalidone Tablets 

Action and useThiazide-like diuretic.

Definition

Chlortalidone Tablets contain Chlortalidone.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of chlortalidone, C14H11ClN2O4S92.5  to 107.5% of the stated amount.
Identification

Heat a quantity of the powdered tablets containing 0.2  g of Chlortalidone with 20  ml of acetone on a water bath for 10  minutes, cool and filter. Add 40  ml of water to the filtrate and heat on a water bath for 20  minutes using a gentle current of air to remove the acetone. Cool the solution to room temperature, allow to stand, filter and dry the crystals at 105° for 4  hours. The infrared spectrum of the crystals, Appendix II A, is concordant with the reference spectrum of chlortalidone (RS 058).


Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using a silica gel F254 precoated plate (Merck silica gel 60 F254 plates are suitable) and a mixture of 5  volumes of toluene, 10  volumes of xylene, 20  volumes of 18m ammonia, 30  volumes of 1,4-dioxan and 30  volumes of propan-2-ol as the mobile phase. Apply separately to the plate 5 µl of each of the following solutions. For solution (1) add a quantity of the powdered tablets containing 0.1  g of Chlortalidone to 5  ml of ethanol (96%), mix with the aid of ultrasound for 15  minutes, centrifuge and use the supernatant liquid. For solution (2) dilute 1  volume of solution (1) to 200  volumes with ethanol (96%). Solution (3) contains 0.020% w/v of 2-(4-chloro-3-sulphamoylbenzoyl)benzoic acid BPCRS in ethanol (96%). After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). Any spot corresponding to 2-(4-chloro-3-sulphamoylbenzoyl)benzoic acid in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (3) (1%) and any other secondary spot is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%).

Assay

Weigh and powder 20  tablets. Boil a quantity of the powder containing 0.1  g of Chlortalidone under a reflux condenser with 30  ml of methanol for 5  minutes, shake vigorously for 15  minutes, cool and filter. Wash the residue and filter with methanol and dilute the combined filtrate and washings to 100  ml with methanol. To 5  ml add 2  ml of 1m hydrochloric acid and sufficient methanol to produce 50  ml and measure the absorbance of the resulting solution at the maximum at 275  nm, Appendix II B. Calculate the content of C14H11ClN2O4S taking 57.4 as the value of A(1%, 1  cm) at the maximum at 275  nm.




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2316

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c) Accept SGS,BV any other third-party inspection before loading.

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Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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