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High Quality USP/EP/BP GMP DMF FDA Chlortetracycline Tablets CAS NO 57-62-5 Producer

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Price: $ 0.08 / Tablet
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  • AZ059
  • Dideu
  • 57-62-5
  • C22H23ClN2O8
  • 200-341-7
  • China
  • Chlortetracycline Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Chlortetracycline Tablets

Action and use

Tetracycline antibacterial.


Chlortetracycline Tablets contain Chlortetracycline Hydrochloride.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of chlortetracycline hydrochloride, C22H23ClN2O8,HCl95.0  to 110.0% of the stated amount.

A.  Carry out the method for thin-layer chromatography, Appendix III A, using silica gel H as the coating substance and a mixture of 6  volumes of water, 35  volumes of methanol and 59  volumes of dichloromethane as the mobile phase. Adjust the pH of a 10% w/v solution of disodium edetate to 8.0 with 10m sodium hydroxide and spray the solution evenly onto the plate (about 10  ml for a plate 100  mm × 200  mm). Allow the plate to dry in a horizontal position for at least 1  hour. At the time of use, dry the plate in an oven at 110° for 1  hour. Apply separately to the plate 1 µl of each of the following solutions. For solution (1) extract a quantity of the powdered tablets containing 10  mg of Chlortetracycline Hydrochloride with 20  ml of methanol and centrifuge. Solution (2) contains 0.05% w/v of chlortetracycline hydrochloride BPCRS in methanol. Solution (3) contains 0.05% w/v each of chlortetracycline hydrochloride BPCRS, tetracycline hydrochloride BPCRS and metacycline hydrochloride EPCRS in methanol. Allow the plate to dry in a stream of air and examine under ultraviolet light (365  nm). The principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2). The test is not valid unless the chromatogram obtained with solution (3) shows three clearly separated spots.

B.  To a quantity of the powdered tablets containing 10  mg of Chlortetracycline Hydrochloride add 20  ml of warm ethanol (96%), allow to stand for 20  minutes, filter and evaporate to dryness on a water bath. A 0.1% w/v solution of the residue in phosphate buffer pH 7.6 when heated at 100° for 1  minute exhibits a strong blue fluorescence in ultraviolet light.


Tetracycline hydrochloride and 4-epichlortetracycline hydrochloride

Not more than 8.0% and 6.0% respectively, determined as described under Assay. Inject separately solutions (1) and (4).


Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900  ml of 0.1m hydrochloric acid and rotate the paddle at 50 revolutions per minute. Withdraw a sample of 10  ml of the medium and filter. Measure the absorbance of the filtered sample, suitably diluted if necessary, at the maximum at 266  nm, Appendix II B. Calculate the total content of chlortetracycline hydrochloride, C22H23ClN2O8,HCl, in the medium taking 346 as the value of A(1%, 1  cm) at the maximum at 266  nm.


Weigh and powder 20  tablets. Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) mix a quantity of the powdered tablets containing 25  mg of Chlortetracycline Hydrochloride with 50  ml of 0.01m hydrochloric acid, shake for 10  minutes, dilute to 100  ml with 0.01m hydrochloric acid and filter (GF/C paper is suitable). Solution (2) contains 0.025% w/v of chlortetracycline hydrochloride BPCRS in 0.01m hydrochloric acid. Solution (3) contains 0.025% w/v each of chlortetracycline hydrochloride BPCRS and 4-epichlortetracycline hydrochloride EPCRS in 0.01m hydrochloric acid. Solution (4) contains 0.002% w/v of tetracycline hydrochloride BPCRS and 0.0015% w/v of 4-epichlortetracycline hydrochloride EPCRS in 0.01m hydrochloric acid.

The chromatographic procedure may be carried out using (a) a stainless steel column (25  cm × 4.6  mm) packed with octadecylsilyl silica gel for chromatography (10 µm) (Nucleosil C18 is suitable) and maintained at 40°, (b) as the mobile phase with a flow rate of 2  ml per minute a mixture of 20  volumes of dimethylformamide and 80  volumes of 0.1m oxalic acid the mixture being adjusted to pH 2.2 with triethylamine and (c) a detection wavelength of 355  nm.

The assay is not valid unless the resolution factor between the two principal peaks in the chromatogram obtained with solution (3) is at least 1.5.

Calculate the content of C22H23ClN2O8,HCl in the tablets using the declared content of C22H23ClN2O8,HCl in chlortetracycline hydrochloride BPCRS.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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