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High Quality USP/EP/BP GMP DMF FDA Clonidine Tablets CAS NO Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ067
  • Dideu
  • C9H9Cl2N3
  • China
  • Clonidine Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Mobile:+86-15129568250; Whatsapp: +8615129568250

Clonidine Tablets

Action and useAlpha2-adrenoceptor agonist; treatment of hypertension.

Definition

Clonidine Tablets contain Clonidine Hydrochloride.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of clonidine hydrochloride, C9H9Cl2N3,HCl

90.0  to 110.0% of the stated amount.

Identification

To a quantity of the powdered tablets containing 0.5  mg of Clonidine Hydrochloride add 30  ml of water and 5  ml of 1m sodium hydroxide. Swirl gently and extract with 20  ml of chloroform. Centrifuge the chloroform layer, dry with anhydrous sodium sulphate, filter and evaporate the filtrate to dryness. Dissolve the residue in 8  ml of 0.01m hydrochloric acid. The resulting solution complies with the following tests.


A.  The light absorption, Appendix II B, in the range 245  to 350  nm exhibits maxima at 272  nm and 279  nm and an inflection at 265  nm.

B.  Add 1  ml of a 10% w/v solution of ammonium reineckate and allow to stand for 5  minutes. A pink precipitate is produced.


Tests

Uniformity of content

Tablets containing less than 2  mg of Clonidine Hydrochloride comply with the requirements stated under Tablets using the following method of analysis.


For tablets containing 0.3  mg or more of Clonidine Hydrochloride, add a suitable volume of citro-phosphate buffer pH 7.6 to one tablet, shake until disintegrated and dilute with citro-phosphate buffer pH 7.6, if necessary, to give a solution containing about 0.0015% w/v of Clonidine Hydrochloride. To 5  ml of the supernatant liquid add 1  ml of a solution containing 0.15% w/v of bromothymol blue and 0.15% w/v of anhydrous sodium carbonate, add 10  ml of chloroform, shake and allow to separate. Filter the chloroform layer through absorbent cotton and dilute 5  ml of the filtrate to 10  ml with boric acid solution. Measure the absorbance of a 2-cm layer of the resulting solution at the maximum at 420  nm, Appendix II B, using 5  ml of boric acid solution diluted to 10  ml with chloroform in the reference cell. Calculate the content of C9H9Cl2N3,HCl from the absorbance obtained by repeating the procedure using a solution prepared by diluting 5  ml of a 0.030% w/v solution of clonidine hydrochloride BPCRS to 100  ml with citro-phosphate buffer pH 7.6, transferring 5  ml to a separating funnel and completing the procedure described above, beginning at the words 'add 1  ml of a solution …' and using the declared content of C9H9Cl2N3,HCl in clonidine hydrochloride BPCRS.


For tablets containing less than 0.3  mg of Clonidine Hydrochloride, use the same procedure but with a concentration of 0.001% w/v or 0.0005% w/v of Clonidine Hydrochloride as appropriate and with correspondingly smaller concentrations of clonidine hydrochloride BPCRS.


Assay

Weigh and powder 20  tablets. To a quantity of the powder containing 0.1  mg of Clonidine Hydrochloride add 25  ml of citro-phosphate buffer pH 7.6 and shake for 15  minutes. Add 5  ml of water and 1  ml of a solution containing 0.15% w/v of bromothymol blue and 0.15% w/v of anhydrous sodium carbonate and shake to disperse. Add 30  ml of chloroform, shake continuously for 1  minute and centrifuge. To 15  ml of the chloroform layer add 10  ml of boric acid solution and measure the absorbance of the resulting solution at the maximum at 420  nm, Appendix II B, using in the reference cell a solution prepared by diluting 10  ml of boric acid solution to 25  ml with chloroform. Repeat the operation using 5  ml of a 0.003% w/v solution of clonidine hydrochloride BPCRS, adding 20  ml of citro-phosphate buffer pH 7.6 and completing the procedure described above, beginning at the words 'Add 5  ml of water …'. Calculate the content of C9H9Cl2N3,HCl in the tablets using the declared content of C9H9Cl2N3,HCl in clonidine hydrochloride BPCRS.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

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a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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