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High quality USP/EP/BP GMP DMF FDA Co-trimoxazole Oral Suspension CAS NO producer

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  • 1 $0.5
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  • AZ576
  • Dideu
  • China
  • Oral Suspension
  • High quality
  • 99.0% Min
  • 99%-101%
  • Oral Suspension
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Co-trimoxazole Oral Suspension 

Action and use

Dihydrofolate reductase inhibitor + sulfonamide antibacterial.


Co-trimoxazole Oral Suspension is a suspension containing 1.6% w/v of Trimethoprim and 8.0% w/v of Sulfamethoxazole in a suitable flavoured vehicle.

Content of trimethoprim, C14H18N4O31.44  to 1.76% w/v.

Content of sulfamethoxazole, C10H11N3O3S 

7.40  to 8.60% w/v.


A.  To a quantity containing 50  mg of trimethoprim add 30  ml of 0.1m sodium hydroxide and extract with four 50  ml quantities of chloroform. Wash the combined extracts with two 10  ml quantities of 0.1m sodium hydroxide and extract with two 50  ml quantities of chloroform. Wash the combined chloroform extracts with two 10  ml quantities of 0.1m sodium hydroxide and then with 10  ml of water. Shake with 5  g of anhydrous sodium sulphate, filter and evaporate to dryness using a rotary evaporator. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of trimethoprim (RS 354).

B.  Carry out the method for thin-layer chromatography, Appendix III A, using silica gel G as the coating substance and a mixture of 100  volumes of chloroform, 10  volumes of methanol and 5  volumes of dimethylformamide as the mobile phase. Apply separately to the plate 5 µl of each of the following solutions. For solution (1) add 20  ml of methanol to 5  ml of the oral suspension, mix, shake with 10  g of anhydrous sodium sulphate, centrifuge and use the supernatant liquid. Solution (2) contains 2.0% w/v of sulfamethoxazole BPCRS in methanol. Solution (3) contains 0.4% w/v of trimethoprim BPCRS in methanol. After removal of the plate, allow it to dry in air and spray with dilute potassium iodobismuthate solution. One of the principal spots in the chromatogram obtained with solution (1) corresponds to the spot in the chromatogram obtained with solution (2) and the other corresponds to the spot in the chromatogram obtained with solution (3).


Related substances


pH, 5.0  to 6.5, Appendix V L.


For trimethoprim

Extract the chloroform solution reserved in the Assay for sulfamethoxazole with four 50  ml quantities of 1m acetic acid. Wash the combined extracts with 5  ml of chloroform and dilute the aqueous extracts to 250  ml with 1m acetic acid. To 10  ml of this solution add 10  ml of 1m acetic acid and sufficient water to produce 100  ml and measure the absorbance of the resulting solution at the maximum at 271  nm, Appendix II B. Calculate the content of C14H18N4O3  taking 204 as the value of A(1%, 1  cm) at the maximum at 271  nm. Using the weight per ml of the oral suspension, calculate the content of C14H18N4O3, weight in volume.

For sulfamethoxazole

To 4  g of the oral suspension add 30  ml of 0.1m sodium hydroxide, shake and extract with four 50  ml quantities of chloroform, washing each extract with the same two 10  ml quantities of 0.1m sodium hydroxide. Reserve the combined chloroform extracts for the Assay for trimethoprim. Dilute the combined aqueous solution and washings to 250  ml with water, filter and dilute 5  ml of the filtrate to 200  ml with water (solution A). Carry out the following procedure protected from light using 2  ml of solution A. Add 0.5  ml of 4m hydrochloric acid and 1  ml of a 0.1% w/v solution of sodium nitrite and allow to stand for 2  minutes. Add 1  ml of a 0.5% w/v solution of ammonium sulphamate and allow to stand for 3  minutes. Add 1  ml of a 0.1% w/v solution of N-(1-naphthyl)ethylenediamine dihydrochloride and allow to stand for 10  minutes. Dilute the resulting solution to 25  ml with water and measure the absorbance at 538  nm, Appendix II B, using in the reference cell a solution prepared in the same manner but using 2  ml of water in place of solution A. Dissolve 0.25  g of sulfamethoxazole BPCRS in 50  ml of 0.1m sodium hydroxide and dilute to 250  ml with water. Dilute 5  ml of the resulting solution to 200  ml with water (solution B). Repeat the procedure using 2  ml of solution B and beginning at the words 'Add 0.5  ml of …'. Calculate the content of C10H11N3O3S from the values of the absorbances obtained using the declared content of C10H11N3O3S in sulfamethoxazole BPCRS. Determine the weight per ml of the oral suspension, Appendix V G, and calculate the content of C10H11N3O3S, weight in volume.


Co-trimoxazole Oral Suspension should be protected from light and stored at a temperature not exceeding 30°.

Co-trimoxazole Oral Suspension contains, in 5  ml, 80  mg of Trimethoprim and 400  mg of Sulfamethoxazole.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Oral Suspension 1Oral Suspension 15Oral Suspension 46

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b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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