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High Quality USP/EP/BP GMP DMF FDA Compound Alginate Antacid Oral Suspension CAS NO Producer

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Price: $ 0.08 / pcs
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ574
  • Dideu
  • China
  • Oral Suspension
  • High quality
  • 99.0% Min
  • 99%-101%
  • Oral Suspension
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Compound Alginate Antacid Oral Suspension 

Definition

Compound Alginate Antacid Oral Suspension is a suspension containing an alginate in a suitable flavoured vehicle. It may be coloured. The suspension has an acid neutralising capacity.

The oral suspension complies with the requirements stated under Oral Liquids and with the following requirements.

Content of aluminium, Al; calcium, Ca; magnesium, Mg; potassium, K; sodium, Na, as appropriate

84.0 to 116.0% of the requisite amount, this being calculated from the stated amounts of the relevant constituents.

Identification

Evaporate to dryness on a water bath a quantity of the oral suspension containing the equivalent of 1  g of the alginate component. The residue complies with the following tests.

A.  Shake 0.2  g in 20 ml of water. To 5  ml of this solution add 1  ml of calcium chloride solution. A  voluminous gelatinous mass is formed.

B.  To 10  ml of the solution prepared in Identification test A add 1  ml of dilute sulphuric acid. A  gelatinous mass is formed.

C.  It complies with the appropriate assays (see Assay).

Tests

Related substances

TESTS

Alkalinity

pH, 7.5 to 9.5, Appendix V L.

Relative density

1.04 to 1.14 g/ml, Appendix V G.

Raft-forming ability

Introduce 150  ml of 0.1m hydrochloric acid into a 250  ml beaker having an internal diameter of 60  to  70  mm. Place in a water bath such that the volume of water in the bath is level with the top of the acid in the beaker and allow to equilibrate to 36.5°  to  37.5°. Using a syringe (without needle), remove a quantity of suspension, previously shaken, equivalent to one dose. Where a dosage range is specified, use the maximum dose. Wipe the outside of the syringe and add the suspension evenly into the centre of the beaker (the time taken to add the entire dose is approximately 5 seconds). After 30 minutes, remove the beaker from the water bath, dry the outside of the beaker and examine the contents. A mass is formed.

Neutralising capacity

Not less than 30  ml of 0.1m hydrochloric acid  VS is required to neutralise 5  ml of the oral suspension when determined by the following method.UR9CQCHS4RXLZ15HKLXE

To 5  ml of the oral suspension, accurately weighed in a 500  ml conical flask, add 250  ml of 0.1m hydrochloric acid  VS and mix well. Place the flask in a water bath maintained at 36.5°  to  37.5° for 1  hour, swirling frequently. Allow to cool and filter. Collect the filtrate in a clean dry flask and titrate to pH  4.0 using 0.5m sodium hydroxide  VS. Calculate the neutralising capacity using the following expression:


UR9CQCHS4RXLZ15HKLXE

where

C1

=

the concentration of 0.1m hydrochloric acid VS in moles per litre,

T

=

the volume of 0.5m sodium hydroxide VS in ml,

C2

=

the concentration of 0.5m sodium hydroxide VS in moles per litre,

Wm

=

the weight per ml of the suspension in g/ml,

W =

the weight of the suspension in g.

Assay

For aluminium

Dilute a quantity of the suspension containing the equivalent of 125 mg of Al, based on the labelled amount, in water to produce 500  ml and filter. Dilute a suitable volume of the filtrate with a solution of strontium chloride such that there is a 1500- to 2000-fold excess of strontium ions in the final solution and determine by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 396  nm. Use aluminium standard solution (200  ppm Al), suitably diluted with the strontium chloride solution, for the standard solutions.

For calcium

Dilute a quantity of the suspension containing the equivalent of 120 mg of Ca, based on the labelled amount, in water to produce 500  ml and filter. Dilute a suitable volume of the filtrate with a solution of strontium chloride such that there is a 1500- to 2000-fold excess of strontium ions in the final solution and determine by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 393  nm. Use calcium standard solution (400  ppm Ca), suitably diluted with the strontium chloride solution, for the standard solutions.

For magnesium

Dilute a quantity of the suspension containing the equivalent of 125 mg of Mg, based on the labelled amount, in water to produce 500  ml and filter. Dilute a suitable volume of the filtrate with a solution of strontium chloride such that there is a 1500- to 2000-fold excess of strontium ions in the final solution and determine by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 285  nm. Use magnesium standard solution (100  ppm Mg), suitably diluted with the strontium chloride solution, for the standard solutions.

For potassium

Dilute a quantity of the suspension containing the equivalent of 120  mg of K, based on the labelled amount, in water to produce 250  ml and filter. Dilute a suitable volume of the filtrate with a solution of strontium chloride such that there is a 1500- to 2000-fold excess of strontium ions in the final solution and determine by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 767  nm. Use potassium standard solution (600  ppm K), suitably diluted with the strontium chloride solution, for the standard solutions. 

For sodium

Dilute a quantity of the suspension containing the equivalent of 125 mg of Na, based on the labelled amount, in water to produce 500  ml and filter. Dilute a suitable volume of the filtrate with a solution of strontium chloride such that there is a 1500- to 2000-fold excess of strontium ions in the final solution and determine by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 589  nm. Use sodium standard solution (200  ppm Na), suitably diluted with the strontium chloride solution, for the standard solutions.

Labelling

The label states (1) the sodium content of the suspension and (2) the potassium content of the suspension, as applicable.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Oral Suspension 1Oral Suspension 15Oral Suspension 46

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

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V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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