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High Quality USP/EP/BP GMP DMF FDA Dapsone Tablets CAS NO 80-08-0 Producer

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Price: $ 0.08 / Tablet
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  • AZ096
  • Dideu
  • 80-08-0
  • C12H12N2O2S
  • 201-248-4
  • China
  • Dapsone Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Dapsone Tablets

Action and use

Folic acid synthesis inhibitor; treatment of leprosy.


Dapsone Tablets contain Dapsone.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of dapsone, C12H12N2O2S

95.0  to 105.0% of the stated amount.

A.  Shake a quantity of the powdered tablets containing 0.1  g of dapsone with 20  ml of acetone, filter and evaporate the filtrate to dryness. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of dapsone (RS 084).

B.  In the test for Related substances, the principal spot in the chromatogram obtained with solution (2) is similar in position, colour and size to that in the chromatogram obtained with solution (5).



Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using 900  ml of 0.1m hydrochloric acid as the medium and rotating the basket at 100 revolutions per minute. Withdraw a sample of 20  ml of the medium. To a volume of the filtered sample expected to contain 0.1  mg of dapsone add 1  ml of a freshly prepared 0.5% w/v solution of sodium nitrite, allow to stand for 3  minutes, add 1.5  ml of a 1% w/v solution of sulphamic acid, allow to stand for 3  minutes, add 2.5  ml of a freshly prepared 0.2% w/v solution of N-(1-naphthyl)-ethylenediamine dihydrochloride in 0.1m hydrochloric acid and dilute to 20  ml with 1m hydrochloric acid (solution A). At the same time carry out the procedure using a volume of 0.1m hydrochloric acid equal to that of the filtered sample and beginning at the words 'add 1  ml of a freshly prepared 0.5% w/v solution of sodium nitrite...' (solution B). Allow solutions A and B to stand for at least 2  minutes and measure the absorbance of solution A at the maximum at 538  nm, Appendix II B, using solution B in the reference cell. Repeat the operation using a solution containing 0.1  mg of dapsone BPCRS in a volume of 0.1m hydrochloric acid equal to that of the filtered sample and beginning at the words 'add 1  ml of a freshly prepared 0.5% w/v solution of sodium nitrite ...'. Calculate the total content of dapsone, C12H12N2O2S, in the medium from the absorbances obtained using the declared content of C12H12N2O2S in dapsone BPCRS.

Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using silica gel G as the coating substance, a mixture of 1  volume of 13.5m ammonia, 6  volumes of methanol, 20  volumes of ethyl acetate and 20  volumes of n-heptane, as the mobile phase and an unsaturated tank. Apply separately to the plate 10 µl of each of solutions (1), (3) and (4) and 1 µl of each of solutions (2) and (5). For solution (1) shake a quantity of the powdered tablets containing 0.1  g of dapsone with 10  ml of methanol and filter. For solution (2) dilute 1  volume of solution (1) to 10  volumes with methanol. For solution (3) dilute 1  volume of solution (2) to 10  volumes with methanol. For solution (4) dilute 1  volume of solution (3) to 5  volumes with methanol. Solution (5) contains 0.1% w/v of dapsone BPCRS. After removal of the plate, allow it to dry in air, spray with a 0.1% w/v solution of 4-dimethylaminocinnamaldehyde in a mixture of 1  volume of hydrochloric acid and 99  volumes of ethanol (96%) and examine in daylight. Any secondary spot in the chromatogram obtained with solution (1) is not more intense that the spot in the chromatogram obtained with solution (3) (1%) and not more than two such spots are more intense than the spot in the chromatogram obtained with solution (4) (0.2%).


Weigh and powder 20  tablets. Dissolve a quantity of the powder containing 0.25  g of dapsone in a mixture of 15  ml of water and 15  ml of 2m hydrochloric acid, add 3  g of potassium bromide, cool in ice and titrate slowly with 0.1m sodium nitrite VS, stirring constantly and determining the end point electrometrically. Each ml of 0.1m sodium nitrite VS is equivalent to 12.42  mg of C12H12N2O2S.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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