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|Action and use|
Diazepam Tablets contain Diazepam.
The tablets comply with the requirements stated under Tablets and with the following requirements.
Content of diazepam, C16H13ClN2O
|92.5 to 107.5% of the stated amount.|
A. The light absorption, Appendix II B, in the range 230 to 350 nm of the final solution obtained in the Assay exhibits two maxima, at 242 nm and 284 nm.
B. Carry out the method for thin-layer chromatography, Appendix III A, using silica gel G as the coating substance and a mixture of 100 volumes of chloroform and 10 volumes of methanol as the mobile phase. Apply separately to the plate 2 µl of each of the following solutions. For solution (1) shake a quantity of the powdered tablets with sufficient methanol to produce a solution containing 0.50% w/v of Diazepam, allow to settle and decant the supernatant liquid. Solution (2) contains 0.5% w/v of diazepam BPCRS in methanol. After removal of the plate, spray it with a 10% v/v solution of sulphuric acid in absolute ethanol, heat at 105° for 10 minutes and examine under ultraviolet light (365 nm). The principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2).
Related substances and decomposition products
Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of equal volumes of ethyl acetate and hexane as the mobile phase but allowing the solvent front to ascend 12 cm above the line of application. Apply separately to the plate (1) 20 µl of a solution freshly prepared by shaking a quantity of the powdered tablets containing 50 mg of Diazepam with 5 ml of ethanol (96%) and filtering and (2) 5 µl of a solution freshly prepared by diluting 1 volume of solution (1) to 50 volumes with ethanol (96%). After removal of the plate, allow the solvent to evaporate and examine under ultraviolet light (254 nm). Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2).
Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using as the medium 900 ml of 0.1m hydrochloric acid and rotating the basket at 100 revolutions per minute. Measure the absorbance of a layer of suitable thickness of the filtered sample, suitably diluted if necessary, with 0.1m hydrochloric acid, at the maximum at 286 nm, Appendix II B, using 0.1m hydrochloric acid in the reference cell. Calculate the total content of diazepam, C16H13ClN2O, in the medium taking 488 as the value of A(1%, 1 cm) at the maximum at 286 nm.
Uniformity of content
Tablets containing 2 mg or less of Diazepam comply with the requirement stated under Tablets using the following method of analysis. To one tablet add 1 ml of water, allow the tablet to disintegrate and stand for 15 minutes. Add 80 ml of a 0.5% w/v solution of sulphuric acid in methanol, shake for 15 minutes, add sufficient of the methanolic sulphuric acid to produce 100 ml and filter. Measure the absorbance of the filtrate at the maximum at 284 nm, Appendix II B. Calculate the content of C16H13ClN2O taking 450 as the value of A(1%, 1 cm) at the maximum at 284 nm.
Weigh and powder 20 tablets. To a quantity of the powder containing 10 mg of Diazepam add 5 ml of water, mix and allow to stand for 15 minutes. Add 70 ml of a 0.5% w/v solution of sulphuric acid in methanol, shake for 15 minutes, add sufficient of the methanolic sulphuric acid to produce 100 ml and filter. Dilute 10 ml of the filtrate to 50 ml with the same solvent and measure the absorbance of the resulting solution at the maximum at 284 nm, Appendix II B. Calculate the content of C16H13ClN2O taking 450 as the value of A(1%, 1 cm) at the maximum at 284 nm.
Diazepam Tablets should be protected from light.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.
a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.