Online

Cart
You are here: Home » Products » Pharmaceutical Ingredient » Antiparasitic » High Quality USP/EP/BP GMP DMF FDA Diethylcarbamazine Tablets CAS NO 90-89-1 Producer
Share to:

High Quality USP/EP/BP GMP DMF FDA Diethylcarbamazine Tablets CAS NO 90-89-1 Producer

5 0 Reviews
Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
sign in to view wholesale price
  • AZ107
  • Dideu
  • 90-89-1
  • C10H21N3O
  • 202-023-3
  • China
  • Diethylcarbamazine Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

Email & Skype: support@dideu.com  Telephone:+86-29-89586682

Mobile:+86-15129568250; Whatsapp: +8615129568250

Diethylcarbamazine Tablets

Action and useAntihelminthic.

Definition

Diethylcarbamazine Tablets contain Diethylcarbamazine Citrate.


The tablets comply with the requirements stated under Tablets and with the following requirements.


Content of diethylcarbamazine citrate, C10H21N3O, C6H8O7

95.0  to 105.0% of the stated amount.
Identification

A.  To a quantity of the powdered tablets containing 0.15 g of Diethylcarbamazine Citrate add 15 ml of ethanol (96%), shake for 5 minutes, filter and evaporate the filtrate to dryness. To the residue add 10 ml of 2m sodium hydroxide, filter if necessary, and extract with three 10-ml quantities of dichloromethane. Dry the combined extracts over anhydrous sodium sulphate, filter and evaporate. The infrared absorption spectrum of the oily residue, Appendix II A, is concordant with the reference spectrum of diethylcarbamazine (RS 411).


B.  In the test for related substances, the chromatogram obtained with solution (1) shows a peak with the same retention time as the peak due to citric acid in the chromatogram obtained with solution (3).

Tests

Dissolution 

Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900 ml of water and rotate the paddle at 50 revolutions per minute. Carry out the method for liquid chromatography, Appendix III D. Dissolve 31.24 g of potassium dihydrogen orthophosphate in water, add sufficient water to produce 1000 ml and mix (solution A). Solution (1) contains 0.0025% w/v of diethylcarbamazine citrate BPCRS in solution A. For solution (2) dilute 10 ml of the filtered dissolution medium with an equal volume of a 6.248% w/v solution of potassium dihydrogen orthophosphate, filter and dilute with solution A to produce a solution expected to contain about 0.0025% w/v of Diethylcarbamazine Citrate.


The chromatographic procedure described under Assay may be used.


Calculate the total content of diethylcarbamazine citrate, C10H21N3O,C6H8O7, in the medium using the declared content of C10H21N3O,C6H8O7 in diethylcarbamazine citrate BPCRS.


Dimethylpiperazine and methylpiperazine 

Carry out the method for thin-layer chromatography, Appendix III A, using silica gel G as the coating substance and a mixture of 5 volumes of 13.5m ammonia, 30 volumes of butan-2-one and 65 volumes of methanol as the mobile phase. Allow the solvent front to ascend 12 cm above the line of application. Apply separately to the plate 20 µl of each of the following solutions. For solution (1) shake a quantity of the powdered tablets containing 0.50 g of Diethylcarbamazine Citrate with 20 ml of methanol and filter. For solution (2) dissolve 0.05 g of diethylcarbamazine citrate BPCRS in methanol and dilute to 2.0 ml with the same solvent. For solution (3) dissolve 10 mg of methylpiperazine in methanol and dilute to 200 ml with the same solvent. For solution (4) dissolve 10 mg of dimethylpiperazine in methanol and dilute to 200 ml with the same solvent. Dry the plate at 105° and expose to iodine vapour for 30 minutes. Any spots corresponding to methylpiperazine and dimethylpiperazine in the chromatogram obtained with solution (1) are not more intense than the spots in the chromatogram obtained with solutions (3) and (4) respectively (0.2% of each).


Related substances

Weigh and finely powder 20 tablets. Dissolve 31.24 g of potassium dihydrogen orthophosphate in water, add sufficient water to produce 1000 ml and mix (solution A). Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) shake a quantity of the powdered tablets containing 0.3 g of Diethylcarbamazine Citrate in 100 ml of solution A, centrifuge and use the clear supernatant liquid. For solution (2) dilute 1 volume of solution (1) to 100 volumes with solution A and further dilute 1 volume of the resulting solution to 10 volumes with solution A to produce a solution containing 0.0003% w/v Diethylcarbamazine Citrate. Solution (3) contains 0.2% w/v of citric acid in solution A. 


The chromatographic procedure described under Assay may be used.


The area of any secondary peak in the chromatogram obtained with solution (1) is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (0.1%). Disregard any peak with the same retention time as citric acid in the chromatogram obtained with solution (1).

Assay

Weigh and finely powder 20 tablets. Dissolve 31.24 g of potassium dihydrogen orthophosphate in water, add sufficient water to produce 1000 ml and mix (solution A). Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) dissolve a quantity of the powdered tablets containing 25 mg of Diethylcarbamazine Citrate in 100 ml of solution A, shake and filter. Dilute 10 volumes to 50 volumes with solution A. Solution (2) contains 0.005% w/v diethylcarbamazine citrate BPCRS in solution A. 


The chromatographic procedure may be carried out using (a) a stainless steel column (15 cm X 3.9 mm) packed with octadecylsilyl silica gel for chromatography (5 µm) (Waters Symmetry is suitable), (b) as the mobile phase with a flow rate of 0.8 ml per minute a mixture of 100 ml of methanol and 900 ml of a solution containing 10 g of potassium dihydrogen orthophosphate in 1000 ml of water and (c) a detection wavelength of 220 nm. 


Calculate the content of C10H21N3O,C6H8O7 in the tablets using the declared content of C10H21N3O,C6H8O7 in diethylcarbamazine citrate BPCRS.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


Quality≥1000Unit,please send inquire:
Online Service

Product Inquiry

Customer Reviews

Trade Alert - Delivering the latest product trends and industry news straight to your inbox.

Customer Services
About Us
Chemicalorigin
Trade Services
 ©2020 Dideu Industries Group Limited