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High Quality USP/EP/BP GMP DMF FDA Diflucortolone Ointment CAS NO 2607-06-9 Producer

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  • AZ525
  • Dideu
  • 2607-06-9
  • C22H28F2O4
  • 220-022-6
  • China
  • Diflucortolone Ointment
  • High quality
  • 99.0% Min
  • 99%-101%
  • Cream
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Diflucortolone Ointment 

Action and useGlucocorticoid.

Definition

Diflucortolone Ointment contains Diflucortolone Valerate in a suitable basis.


The ointment complies with the requirements stated under Topical Semi-solid Preparations and with the following requirements.

Content of diflucortolone valerate, C27H36F2O5

90.0  to 110.0% of the stated amount.

Identification

A.  Carry out the method for thin-layer chromatography, Appendix III A, using a silica gel 60 F254 precoated plate (Merck silica gel 60 plates are suitable) and a mixture of 2  volumes of diethylamine, 50  volumes of cyclohexane and 50  volumes of ethyl acetate as the mobile phase. Apply separately to the plate 10 µl of each of the following solutions. For solution (1) disperse a quantity of the ointment containing 1  mg of Diflucortolone Valerate in 5  ml of dichloromethane by heating on a water bath, shake vigorously for 15  seconds, cool in ice, filter the dispersion and use the filtrate. Solution (2) contains 0.02% w/v of diflucortolone valerate BPCRS in dichloromethane. Solution (3) contains a mixture of equal volumes of solutions (1) and (2). Develop the chromatogram twice, drying the plate in air for 15  minutes between developments. After removal of the plate, allow it to dry in air for 15  minutes and examine under ultraviolet light (254  nm). The principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2). The principal spot in the chromatogram obtained with solution (3) appears as a single compact spot.


B.  In the Assay, the chromatogram obtained with solution (2) shows a peak with the same retention time as the peak due to diflucortolone valerate in the chromatogram obtained with solution (1).

Assay

Carry out the method for liquid chromatography, Appendix III D, injecting 20 µl of each of the following solutions. For solution (1) dissolve 20  mg of diflucortolone valerate BPCRS in a 0.02% w/v solution of clocortolone hexanoate BPCRS (internal standard) in methanol and dilute to 200  ml with the internal standard solution. Add 30  ml of methanol to 10  ml of the resulting solution and dilute to 50  ml with water. For solution (2) shake a quantity of the ointment containing 1  mg of Diflucortolone Valerate with 10  ml of a 0.02% w/v solution of clocortolone hexanoate BPCRS in methanol and add 30  ml of methanol. Disperse by heating on a water bath at 60° for 5  minutes and shake for 30  seconds. Add 10  ml of water, cool in ice for 10  minutes and filter.


The chromatographic procedure described under Diflucortolone Cream may be used.


Calculate the content of C27H36F2O5 in the ointment using the declared content of C27H36F2O5 in diflucortolone valerate BPCRS.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Cream 9Cream 11Cream 86

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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