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High Quality USP/EP/BP GMP DMF FDA Disulfiram Tablets CAS NO 97-77-8 Producer

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  • AZ125
  • Dideu
  • 97-77-8
  • C10H20N2S4
  • 202-607-8
  • China
  • Disulfiram Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

Email & Skype: support@dideu.com  Telephone:+86-29-89586682

Mobile:+86-15129568250; Whatsapp: +8615129568250

Disulfiram Tablets

Action and use

Aldehyde dehyrogenase inhibitor; treatment of alcoholism.

Definition

Disulfiram Tablets contain Disulfiram.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of disulfiram, C10H20N2S4

95.0  to 105.0% of the stated amount.
Identification

A.  Extract a quantity of the powdered tablets containing 0.2  g of Disulfiram by shaking with 5 ml of dichloromethane and filter. Evaporate the filtrate to dryness and dry the residue at 40° at a pressure not exceeding 0.7  kPa. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of disulfiram (RS 111).


B.  In the test for Related substances, the principal spot in the chromatogram obtained with solution (2) corresponds to that in the chromatogram obtained with solution (3).


C.  Extract a quantity of the powdered tablets containing 0.3  g of disulfiram with ethanol (96%), filter and evaporate the filtrate to dryness. Dissolve 50  mg of the residue in 5  ml of ethanol (96%) and add 1  ml of potassium cyanide solution. A yellow colour is produced which becomes green and then darkens to bluish green.

Tests

Related substances

Diethyldithiocarbamate

Shake a quantity of the powdered tablets containing 0.1  g of Disulfiram with 10  ml of chloroform and filter. Add 10  ml of 0.1m sodium hydroxide to the filtrate, shake, discard the chloroform layer and wash the aqueous layer with three 10  ml quantities of chloroform. To the aqueous layer add 0.25  ml of a 0.4% w/v solution of copper(ii) sulphate and 2  ml of dichloromethane, shake and allow to separate. The lower layer is not more intensely coloured than a standard prepared at the same time and in the same manner by adding 10  ml of 0.1m sodium hydroxide to 0.2  ml of a freshly prepared 0.0075% w/v solution of sodium diethyldithiocarbamate and beginning at the words 'add 0.25  ml of a 0.4% w/v solution of copper(II) sulphate ...' (0.01%, calculated as the acid).


Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of 30  volumes of butyl acetate and 70  volumes of n-hexane as the mobile phase. Apply separately to the plate 10 µl of each of the following solutions. For solution (1) extract a quantity of the powdered tablets containing 0.50  g of Disulfiram with 20  ml of ethyl acetate and filter. For solution (2) dilute 1  volume of solution (1) to 100  volumes with ethyl acetate. Solution (3) contains 0.025% w/v of disulfiram BPCRS in ethyl acetate. Solution (4) contains 0.050% w/v of monosulfiram BPCRS in ethyl acetate. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). In the chromatogram obtained with solution (1) any spot corresponding to monosulfiram is not more intense than the spot in the chromatogram obtained with solution (4) (2%) and any other secondary spot is not more intense than the spot in the chromatogram obtained with solution (2) (1%).

Assay

Weigh and powder 20  tablets. To a quantity of the powder containing 0.4  g of Disulfiram add 75  ml of methanol and shake for 30  minutes. Add sufficient methanol to produce 100  ml, filter and dilute 5  ml of the filtrate to 100  ml with methanol. To 5  ml of this solution add sufficient of a 0.1% w/v solution of copper(ii) chloride in methanol to produce 25  ml, mix and allow to stand for 1  hour. Measure the absorbance of the resulting solution at the maximum at 400  nm, Appendix II B, using in the reference cell a solution prepared by diluting 5  ml of methanol to 25  ml with the copper(II) chloride solution. Repeat the operation using 5  ml of a 0.020% w/v solution of disulfiram BPCRS in methanol, beginning at the words 'add sufficient of a 0.1% w/v solution of copper(ii) chloride …'. Calculate the content of C10H20N2S4 from the absorbances obtained and using the declared content of C10H20N2S4 in disulfiram BPCRS.

Storage

Disulfiram Tablets should be protected from light.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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