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High Quality USP/EP/BP GMP DMF FDA Dosulepin Capsules CAS NO 113-53-1 Producer

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Price: $ 0.08 / pcs
min order: 1 pcs
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ409
  • Dideu
  • 113-53-1
  • C19H21NS
  • 204-031-2
  • China
  • Dosulepin Capsules
  • High quality
  • 99.0% Min
  • 99%-101%
  • Capsule
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Dosulepin Capsules 

Action and use

Monoamine reuptake inhibitor; tricyclic antidepressant.


Dosulepin Capsules contain Dosulepin Hydrochloride.

The capsules comply with the requirements stated under Capsules and with the following requirements.

Content of dosulepin hydrochloride, C19H21NS,HCl

92.5  to 107.5% of the stated amount.

Extract a quantity of the contents of the capsules containing 0.1  g of Dosulepin Hydrochloride with 20  ml of absolute ethanol, filter and remove the ethanol from the filtrate by evaporation. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of dosulepin hydrochloride (RS 114).


Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions.

(1)  Extract a quantity of the contents of the capsules containing 0.25  g of Dosulepin Hydrochloride by shaking for 2  minutes with 5  ml of chloroform, centrifuge and use the supernatant liquid.

(2)  Dilute 2  ml of solution (1) to 5  ml with chloroform.

(3)  0.010% w/v each of 3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethylaminopropan-1-amine S-oxide hydrochloride BPCRS and dibenzo[b,e]thiepin-11(6H)-one BPCRS in chloroform.

chromatographic conditions

(a)  Use a TLC silica gel 60 F254 precoated plate (Merck silica gel 60 F254 plates are suitable).

(b)  Use the mobile phase as described below. 

(c)  Apply 5 µl of each solution.

(d)  Develop the plate to 15 cm.

(e)  After removal of the plate, dry in air and examine under ultraviolet light (254  nm).

mobile phase

1  volume of 13.5m ammonia, 10  volumes of propan-2-ol and 90  volumes of 1,2-dichloroethane.


The spot with the lower Rf value in the chromatogram obtained with solution (3) is more intense than any corresponding spot in the chromatogram obtained with solution (2) (0.5%). 

In the chromatogram obtained with solution (1), any secondary spot other than any spot corresponding to the spot with the lower Rf value in the chromatogram obtained with solution (3) is not more intense than the proximate spot in the chromatogram obtained with solution (3) (0.2%).


Carry out the method for gas chromatography, Appendix III B.

(1)  Extract a quantity of the mixed contents of 20 capsules containing 25  mg of Dosulepin Hydrochloride with 5  ml of methanol, centrifuge and use the supernatant liquid.

(2)  0.50% w/v of dosulepin hydrochloride BPCRS in methanol.

chromatographic conditions

(a)  Use a glass column (1.8 m × 3  mm) packed with acid-washed, silanised diatomaceous support (100  to 120  mesh) coated with 3% w/w of cyanopropylmethyl phenyl methyl silicone fluid (OV-225 is suitable).

(b)  Use helium as the carrier gas at 1.7 ml per minute.

(c)  Use isothermal conditions maintained at 200°.

(d)  Use an inlet temperature of 200°.

(e)  Use a flame ionisation detector at a temperature of 200°.

(f)  Inject 1 µl of each solution.


In the chromatogram obtained with solution (1) a peak due to Z-dosulepin is present with a retention time of approximately 0.83 relative to the retention time of the principal peak which is due to E-dosulepin. 

In the chromatogram obtained with solution (2) the area of any peak corresponding to Z-dosulepin is not greater than 7.5% of the sum of the areas of the peaks due to Z-dosulepin and E-dosulepin.


Extract a quantity of the mixed contents of 20 capsules containing 0.5  g of Dosulepin Hydrochloride with 20  ml followed by four 10  ml quantities of chloroform, filtering each extract through the same filter. Evaporate the combined extracts to dryness, dissolve the residue in 100  ml of acetone, add 10  ml of mercury(ii) acetate solution and carry out Method I for non-aqueous titration, Appendix VIII A, using 3  ml of a saturated solution of methyl orange in acetone as indicator. Each ml of 0.1m perchloric acid VS is equivalent to 33.19  mg of C19H21NS,HCl.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Capsules 1CapsulesCapsules 106

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Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

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Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

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We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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