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Ferrous Fumarate Oral Suspension
Ferrous Fumarate Oral Suspension is a suspension of ferrous fumarate in a suitable flavoured vehicle.
The oral suspension complies with the requirements stated under Oral Liquids and with the following requirements.
Content of ferrous iron, Fe(ii)
90.0 to 110.0% of the stated amount.
A. Mix a volume of the oral suspension containing about 0.6 g of ferrous fumarate with 20 ml of water, centrifuge and discard the supernatant liquid. Repeat with a further 20 ml of water. Add 15 ml of 3m hydrochloric acid to the residue, dissolve with minimum warming, cool and extract with two 50 ml quantities of ether. Wash the combined ether extracts with two 20 ml quantities of water, shake with anhydrous sodium sulphate, filter and evaporate to dryness. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of fumaric acid (RS 163).
B. Mix a volume of the oral suspension containing about 0.3 g of ferrous fumarate in 10 ml of water, centrifuge and discard the supernatant liquid. To 0.2 g of the residue add 10 ml of a mixture of equal volumes of hydrochloric acid and water, dissolve with minimum warming, cool and filter. The filtrate yields reaction A characteristic of iron salts, Appendix VI.
Disperse a quantity of the oral suspension containing 0.28 g of ferrous fumarate in 20 ml of water, centrifuge and decant the supernatant liquid into a 500 ml graduated flask. Dissolve the residue in 20 ml of 1m sulphuric acid with minimum warming, cool and transfer the resulting solution to the same graduated flask, dilute to 500 ml with water and filter. To 5 ml of the filtrate in a Nessler cylinder add 40 ml of water and 5 ml of a 10% w/v solution of ammonium thiocyanate and mix. Any red colour produced is not more intense than that obtained by treating in the same manner a mixture of 42 ml of water, 0.2 ml of 1m sulphuric acid and 3 ml of a 0.0173% w/v solution of ammonium iron(iii) sulphate in 0.01m hydrochloric acid [6.0%, with respect to the content of Fe(ii)].
|Assay||Mix a quantity of the oral suspension containing 0.28 g of ferrous fumarate with 10 ml of water and 25 ml of nitric acid, carefully warm until the vigorous reaction subsides, add a further 25 ml of nitric acid, evaporate to about 10 ml and allow to cool. Carefully add 10 ml of sulphuric acid to the cooled solution, evaporate until white fumes are evolved, cool, add 10 ml of nitric acid and again evaporate until white fumes are evolved. Repeat the evaporation with 10 ml quantities of nitric acid until all of the organic matter has been destroyed. To the resulting solution add 10 ml of water and 0.5 g of ammonium oxalate, evaporate until white fumes are evolved, add 50 ml of water, boil until a clear solution is obtained, cool, dilute to 100 ml with water and add dilute potassium permanganate solution, drop wise, until a faint pink colour persists for 10 seconds. Add 10 ml of hydrochloric acid and 3 g of potassium iodide, allow to stand for 15 minutes protected from light, add 10 ml of chloroform and titrate the liberated iodine with 0.1m sodium thiosulphate VS, with vigorous shaking, until the chloroform layer becomes colourless. Repeat the procedure without the preparation being examined. The difference between the titrations represents the amount of sodium thiosulphate required. Each ml of 0.1m sodium thiosulphate VS is equivalent to 5.585 mg of Fe(ii).|
|Storage||Ferrous Fumarate Oral Suspension should be protected from light.|
The quantity of the active ingredient is stated both as the amount of ferrous fumarate and in terms of the equivalent amount of ferrous iron.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.
a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.
Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.
At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.
Dideu Industries Consist Of Five Industry Chains:
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
VI)General Chemical Industry
At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.
At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.
We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.