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High Quality USP/EP/BP GMP DMF FDA Fluphenazine Tablets CAS NO 69-23-8 Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ160
  • Dideu
  • 69-23-8
  • C22H26F3N3OS
  • 200-702-9
  • China
  • Fluphenazine Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Fluphenazine Tablets 

Action and use

Dopamine receptor antagonist; neuroleptic.

Definition

Fluphenazine Tablets contain Fluphenazine Hydrochloride. They are coated.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of fluphenazine hydrochloride, C22H26F3N3OS,2HCl

90.0  to 110.0% of the stated amount.
Identification

A.  Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using kieselguhr G as the coating substance. Impregnate the dry plate by placing it in a tank containing a shallow layer of a mixture of 5  volumes of 2-phenoxyethanol, 15  volumes of formamide and 180  volumes of acetone, allowing the impregnating solvent to ascend to the top, removing the plate from the tank and using it immediately. Use a mixture of 2  volumes of diethylamine and 100  volumes of petroleum spirit (boiling range, 40° to 60°) saturated with 2-phenoxyethanol as the mobile phase. Apply separately to the plate 2 µl of each of the following solutions. For solution (1) shake a quantity of the powdered tablets with sufficient methanol to produce a solution containing 0.2% w/v of fluphenazine hydrochloride, centrifuge and use the supernatant liquid. Solution (2) contains 0.2% w/v of fluphenazine hydrochloride BPCRS in methanol. After removal of the plate, allow it to dry in air, examine under ultraviolet light (365  nm) and observe the fluorescence produced after about 2  minutes. Heat the plate at 120° for 20  minutes, cool, spray with ethanolic sulphuric acid (20%) and observe the colour produced. The principal spot in the chromatogram obtained with solution (1) corresponds in position, fluorescence and colour to that in the chromatogram obtained with solution (2).


B.  Extract a quantity of the powdered tablets containing 5  mg of fluphenazine hydrochloride with 5  ml of acetone, filter and evaporate the filtrate to dryness. Add 2  ml of sulphuric acid to the residue and allow to stand for 5  minutes. An orange colour is produced.


C.  Extract a quantity of the powdered tablets containing 10  mg of fluphenazine hydrochloride with 10  ml of absolute ethanol containing 0.2% v/v of 13.5m ammonia and evaporate the extract to dryness. Heat 0.5  ml of chromic–sulphuric acid mixture in a small test tube in a water bath for 5  minutes; the solution wets the side of the tube readily and there is no greasiness. Add 2 or 3  mg of the residue and again heat in a water bath for 5  minutes; the solution does not wet the side of the tube and does not pour easily from the tube.

Tests

Related substances

Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of 5  volumes of 13.5m ammonia, 30  volumes of cyclohexane and 80  volumes of acetone as the mobile phase. Apply separately to the plate 50 µl of solution (1) and 25 µl of each of solutions (2) and (3). For solution (1) remove the coating from a suitable number of tablets; shake a quantity of the powdered tablet cores containing 20  mg of fluphenazine hydrochloride with 10  ml of 0.1m methanolic sodium hydroxide for 5  minutes, centrifuge and use the supernatant liquid. For solution (2) dilute 1  volume of solution (1) to 50  volumes with 0.1m methanolic sodium hydroxide. For solution (3) dilute 1  volume of solution (1) to 100  volumes with 0.1m methanolic sodium hydroxide. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (1%) and not more than two such spots are more intense than the spot in the chromatogram obtained with solution (3) (0.5%). Disregard any spot remaining on the line of application.


Uniformity of content

Tablets containing less than 2  mg of fluphenazine hydrochloride comply with the requirements stated under Tablets using the following method of analysis. Carry out the following procedure protected from light. Record second-derivative ultraviolet absorption spectra of the following solutions in the range 230  to 300  nm, Appendix II B. For solution (1) add 2  ml of 0.1m hydrochloric acid to one tablet and mix with the aid of ultrasound until the tablet is dispersed. Add 60  ml of a mixture of 1  volume of 1m hydrochloric acid and 99  volumes of ethanol (80%), shake for 20  minutes, dilute to 100  ml with the same solvent mixture, mix and filter. Solution (2) contains 0.001% w/v of fluphenazine hydrochloride BPCRS.


For each solution measure the amplitude from the peak at about 266  nm to the trough at about 258  nm. Calculate the content of C22H26F3N3OS,2HCl in each tablet using the declared content of C22H26F3N3OS,2HCl in fluphenazine hydrochloride BPCRS.

Assay

For tablets containing 2  mg or more of fluphenazine hydrochloride

Carry out the following procedure protected from light. Record second-derivative ultraviolet absorption spectra of the following solutions in the range 230  to 300  nm, Appendix II B. For solution (1) add 20  ml of 0.1m hydrochloric acid to 10  tablets, mix with the aid of ultrasound until the tablets are dispersed, add 600  ml of a mixture of 1  volume of 1m hydrochloric acid and 99  volumes of ethanol (80%), shake for 20  minutes, dilute to 1000  ml with the same solvent mixture, mix and filter. Solution (2) contains 0.001% w/v of fluphenazine hydrochloride BPCRS.


For each solution measure the amplitude from the peak at about 266  nm to the trough at about 258  nm. Calculate the content of C22H26F3N3OS,2HCl in the tablets using the declared content of C22H26F3N3OS,2HCl in fluphenazine hydrochloride BPCRS.


For tablets containing less than 2  mg of fluphenazine hydrochloride

Use the average of the 10 individual results obtained in the test for Uniformity of content.





The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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