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High Quality USP/EP/BP GMP DMF FDA Furosemide Tablets CAS NO 54-31-9 Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ165
  • Dideu
  • 54-31-9
  • C12H11ClN2O5S
  • 200-203-6
  • China
  • Furosemide Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Furosemide Tablets

Action and use

Loop diuretic.

Definition

Furosemide Tablets contain Furosemide.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of furosemide, C12H11ClN2O5S

95.0  to 105.0% of the stated amount.
Identification

A.  The light absorption, Appendix II B, in the range 220  to 320  nm of the final solution obtained in the Assay exhibits two maxima, at 228  nm and 271  nm.

B.  In the test for Related substances, the principal peak in the chromatogram obtained with solution (2) shows a peak with the same retention time as the principal peak in the chromatogram obtained with solution (3).

Tests

Dissolution

Tablets containing less than 100  mg of Furosemide comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900  ml of phosphate buffer pH 5.8 and rotate the paddle at 50 revolutions per minute. Withdraw a sample of 10  ml of the medium, filter and dilute the filtrate with sufficient of the dissolution medium to give a solution expected to contain about 0.001% w/v of Furosemide. Measure the absorbance of this solution, Appendix II B, at 277  nm using dissolution medium in the reference cell. Calculate the total content of furosemide, C12H11ClN2O5S, in the medium from the absorbance obtained from a 0.001% w/v solution of furosemide BPCRS in the dissolution medium and using the declared content of C12H11ClN2O5S in furosemide BPCRS.


Related substances

Carry out the method for liquid chromatography, Appendix III D, using the following solutions. Prepare the solutions immediately before use and protect from light. For solution (1) dissolve a quantity of the powdered tablets containing 20  mg of Furosemide in sufficient of the mobile phase to produce 50  ml and mix with the aid of ultrasound for 15  minutes. For solution (2) dilute 1  volume of solution (1) to 500  volumes with the mobile phase. Solution (3) contains 0.00008% w/v of furosemide BPCRS in the mobile phase. Solution (4) contains 0.00008% w/v of each of furosemide BPCRS and furosemide impurity A EPCRS in the mobile phase. Solution (5) contains 0.00032% w/v of 4-chloro-5-sulphamoylanthranilic acid BPCRS in the mobile phase.


The chromatographic procedure may be carried out using (a) a stainless steel column (25  cm × 4.6  mm) packed with octylsilyl silica gel for chromatography (5 µm) (ChromSpher C8 is suitable), (b) as the mobile phase with a flow rate of 1  ml per minute a mixture prepared in the following manner: dissolve 0.2  g of potassium dihydrogen orthophosphate and 0.25  g of cetrimide in 70  ml of water, adjust the pH to 7.0 with 6m ammonia and add 30  ml of propan-1-ol and (c) a detection wavelength of 238  nm.


Inject 100 µl of solution (4). Adjust the sensitivity of the system so that the heights of the two peaks in the chromatogram obtained are not less than 20% of the full-scale of the recorder. The test is not valid unless the resolution factor between the first peak (furosemide impurity A) and the second peak (furosemide) is at least 4.


Inject 100 µl of solution (1) and allow the chromatography to proceed for three times the retention time of the principal peak. In the chromatogram obtained with solution (1) the area of any peak corresponding to 4-chloro-5-sulphamoylanthranilic acid is not greater than the area of the peak in the chromatogram obtained with solution (5) (0.8%) and the sum of the areas of any other secondary peaks is not greater than 2.5  times the area of the first peak in the chromatogram obtained with solution (4) (0.5%). Disregard any peak with an area less than 0.1  times the area of the first peak in the chromatogram obtained with solution (4) (0.02%).

Assay

Weigh and powder 20  tablets. Shake a quantity of the powder containing 0.2  g of Furosemide with 300  ml of 0.1m sodium hydroxide for 10  minutes, add sufficient 0.1m sodium hydroxide to produce 500  ml and filter. Dilute 5  ml to 250  ml with 0.1m sodium hydroxide and measure the absorbance of the resulting solution at the maximum at 271  nm, Appendix II B. Calculate the content of C12H11ClN2O5S taking 580 as the value of A(1%, 1  cm) at the maximum at 271  nm.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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