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High Quality USP/EP/BP GMP DMF FDA Gliquidone Tablets CAS NO 33342-05-1 Producer

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Price: $ 0.08 / Tablet
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  • AZ180
  • Dideu
  • 33342-05-1
  • C27H33N3O6S
  • 251-463-2
  • China
  • Gliquidone Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Gliquidone Tablets

Action and use

Inhibition of ATP-dependent potassium channels (sulfonylurea); treatment of diabetes mellitus.


Gliquidone Tablets contain Gliquidone.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of gliquidone, C27H33N3O6S

95.0  to 105.0% of the stated amount.

A.  Extract a quantity of the powdered tablets containing 30  mg of Gliquidone in 10  ml of methanol with the aid of ultrasound, filter, evaporate the filtrate to dryness using a rotary evaporator and dry the residue at a temperature of 50° at a pressure of 2  kPa for 1  hour. The infrared absorption spectrum of the dried residue, Appendix II A, is concordant with the reference spectrum of gliquidone (RS 170) .

B.  In the test for Related substances, the principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2).



Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules , Appendix XII B1, using Apparatus 2. Use as the medium 900  ml of a citro-phosphate buffer prepared by dissolving 35.6  g of disodium hydrogen orthophosphate dihydrate in sufficient water to produce 1000  ml, adjusting the pH to 8.5 with citric acid , and rotate the paddle at 75 revolutions per minute. Withdraw a sample of 50  ml of the medium and filter (Whatman No. 1 filter paper is suitable), discarding the first 15  ml of filtrate. Measure the absorbance of the filtered solution, Appendix II B, at the maximum at 314  nm using a filtered solution of the dissolution medium in the reference cell. Measure the absorbance of a solution of gliquidone BPCRS prepared in the following manner. Dissolve about 30  mg of gliquidone BPCRS in 10  ml of dimethylformamide , add sufficient dissolution medium to produce 100  ml and mix. Dilute 10  ml of this solution to 100  ml with dissolution medium, mix and filter (Whatman No. 1 filter paper is suitable), discarding the first 15  ml of filtrate. Calculate the total content of gliquidone, C27H33N3O6S, in the medium from the absorbances obtained and from the declared content of C27H33N3O6S in gliquidone BPCRS .

Related substances

Carry out the method for thin-layer chromatography , Appendix III A, using silica gel GF 254 as the coating substance and a mixture of 5  volumes of glacial acetic acid , 5  volumes of ethanol (96%) , 45  volumes of chloroform and 45  volumes of cyclohexane as the mobile phase but allowing the solvent front to ascend 10  cm above the line of application. Apply separately to the plate 10 µl of each of the following five solutions. For solution (1) mix a quantity of the powdered tablets containing 0.1  g of Gliquidone with 8  ml of a mixture of 50  volumes of dichloromethane and 50  volumes of methanol , mix with the aid of ultrasound for 10  minutes, add sufficient of the same solvent mixture to produce 10  ml, filter (Whatman GF/C filter paper is suitable) and use the filtrate. Solution (2) contains 1.0% w/v of gliquidone BPCRS in a mixture of 50  volumes of dichloromethane and 50  volumes of methanol . Solution (3) contains 0.0030% w/v of gliquidone BPCRS in a mixture of 50  volumes of dichloromethane and 50  volumes of methanol . Solution (4) contains 0.010% w/v of gliquidone sulphonamide BPCRS in a mixture of 50  volumes of dichloromethane and 50  volumes of methanol . For solution (5) mix 1  volume of solution (3) and 1  volume of solution (4). After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm) . In the chromatogram obtained with solution (1) any spot corresponding to gliquidone sulphonamide is not more intense than the spot in the chromatogram obtained with solution (4) (1%) and any other secondary spot is not more intense than the spot in the chromatogram obtained with solution (3) (0.3%). The test is not valid unless the chromatogram obtained with solution (5) shows two clearly separated principal spots.


Weigh and powder 20  tablets. To a quantity of the powdered tablets containing 0.1  g of Gliquidone add 50  ml of methanol , mix with the aid of ultrasound for 10  minutes, allow to cool, add sufficient methanol to produce 100  ml and filter. Dilute 15  ml of the filtrate to 100  ml with methanol and measure the absorbance of the resulting solution at the maximum at 310  nm, Appendix II B. Calculate the content of C27H33N3O6S in the tablets from the absorbance of a 0.015% w/v solution of gliquidone BPCRS in methanol and using the declared content of C27H33N3O6S in gliquidone BPCRS .

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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