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High Quality USP/EP/BP GMP DMF FDA Methadone Tablets CAS NO 76-99-3 Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ222
  • Dideu
  • 76-99-3
  • C21H27NO
  • 200-996-9
  • China
  • Methadone Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Mobile:+86-15129568250; Whatsapp: +8615129568250

Methadone Tablets 

Action and use

Opioid receptor agonist; analgesic.

Definition

Methadone Tablets contain Methadone Hydrochloride.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of methadone hydrochloride, C21H27NO,HCl

92.5  to 107.5% of the stated amount.
Identification

A.  Shake a quantity of the powdered tablets containing 0.1  g of Methadone Hydrochloride with 20  ml of water and centrifuge. Make the supernatant liquid alkaline with 5m sodium hydroxide , stir with a glass rod until the precipitate solidifies, filter, wash with water and dry over phosphorus pentoxide at room temperature at a pressure of 2  kPa. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of methadone (RS 218) .


B.  Extract a quantity of the powdered tablets containing 0.1  g of Methadone Hydrochloride with 10  ml of water, filter and wash the residue with sufficient water to bring the volume of the filtrate to 10  ml. Add to the filtrate 0.125  g of picrolonic acid dissolved in 50  ml of boiling water, stir and allow to stand for 2  hours. The melting point of the residue, after recrystallisation from ethanol (20%), washing with ethanol (20%) and drying at 105°, is about 160° or about 180°, Appendix V A.


C.  Extract a quantity of the powdered tablets containing 5  mg of Methadone Hydrochloride with 5  ml of ethanol (96%) , filter and evaporate the filtrate to dryness. To the residue add 0.05  ml of dinitrobenzene solution and 0.05  ml of a 50% w/v solution of sodium hydroxide . A purple colour is produced which changes slowly to dark brown.

Assay

Weigh and powder 20  tablets. To a quantity of the powder containing 50  mg of Methadone Hydrochloride add 60  ml of water and 5  ml of glacial acetic acid , heat on a water bath for 5  minutes, mix with the aid of ultrasound for 10  minutes and dilute to 100  ml with water. Filter through a glass fibre paper, discarding the first 10  ml of filtrate, and dilute 20  ml to 100  ml with water. To 10  ml of the resulting solution add 10  ml of phosphate buffer pH 4.9 and 5  ml of a 0.4% w/v solution of picric acid . Extract with three 15  ml quantities of chloroform and dilute the combined chloroform extracts to 50  ml with chloroform . To 10  ml add sufficient chloroform to produce 20  ml and measure the absorbance of the resulting solution, Appendix II B, at the maximum at 350  nm using in the reference cell a solution prepared in the same manner but using a 5% v/v solution of glacial acetic acid and beginning at the words 'Filter through a glass fibre paper…'. Calculate the content of C21H27NO,HCl taking 448 as the value of A (1%, 1  cm) at the maximum at 350  nm.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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