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High Quality USP/EP/BP GMP DMF FDA Methylphenobarbital Tablets CAS NO 115-38-8 Producer

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Price: $ 0.08 / Tablet
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  • AZ226
  • Dideu
  • 115-38-8
  • C13H14N2O3
  • 204-085-7
  • China
  • Methylphenobarbital Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Methylphenobarbital Tablets 

Action and use

Barbiturate.

Definition

Methylphenobarbital Tablets contain Methylphenobarbital.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of methylphenobarbital, C13H14N2O3

95.0  to 105.0% of the stated amount.
Identification

A.  Transfer a quantity of the finely powdered tablets containing 0.20  g of Methylphenobarbital to a long-stemmed, sintered glass filter (ISO 4793, porosity grade 3, is suitable), wash with 15  ml of petroleum ether (boiling range 40° to 60°), stir for 2  to 3  minutes and filter; repeat the extraction with two 15  ml quantities of petroleum ether (boiling range 40° to 60°). Discard the filtrates, extract the residues with two 15  ml quantities of dichloromethane, combine the extracts, evaporate to dryness on a water bath and dry the residue at 105° for 30  minutes to 1  hour. The infrared absorption spectrum of the dried residue, Appendix II A, is concordant with the reference spectrum of methylphenobarbital (RS 388).


B.  In the Assay, the chromatogram obtained with solution (1) shows a peak with the same retention time as the principal peak in the chromatogram obtained with solution (2).

Tests

Dissolution

Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2 and rotating the paddle at 75 revolutions per minute. Use as the medium 900  ml of a borate buffer of pH 10.0 prepared by dissolving 3.093  g of boric acid, 3.730  g of potassium chloride and 1.75  g of sodium hydroxide in 200  ml of water and diluting the solution to 1000  ml with water. Withdraw a sample of 20  ml of the medium and filter. Dilute the filtrate, if necessary, with the dissolution medium to give a solution expected to contain about 0.002% w/v of Methylphenobarbital. Measure the absorbance of this solution, Appendix II B, at the maximum at 242  nm using dissolution medium in the reference cell. Calculate the total content of methylphenobarbital, C13H14N2O3, in the medium from the absorbance obtained from a 0.0020% w/v solution of methylphenobarbital BPCRS in dissolution medium and using the declared content of C13H14N2O3 in methylphenobarbital BPCRS.


Related substances

Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) add 120  ml of methanol to a quantity of the powdered tablets containing 30  mg of Methylphenobarbital, mix with the aid of ultrasound for 10  minutes, add 50  ml of water, cool and dilute to 200  ml with methanol. For solution (2) dilute 1  volume of solution (1) to 100  volumes with methanol (75%).


The chromatographic procedure may be carried out using (a) a stainless steel column (15  cm × 4.6  mm) packed with particles of silica 5 µm in diameter the surface of which has been modified with chemically bonded hexyl groups (Spherisorb Hexyl is suitable) and maintained at 40°, (b) as the mobile phase with a flow rate of 2  ml per minute a mixture of 55  volumes of 0.045m disodium hydrogen orthophosphate adjusted to pH 6.5 with orthophosphoric acid and 45  volumes of methanol, adjusted to pH 6.0 with orthophosphoric acid and (c) a detection wavelength of 235  nm.


Inject 20 µl of each solution. In the chromatogram obtained with solution (1) the sum of the areas of any secondary peaks is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (1%).

Assay

Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) add 120  ml of methanol to a quantity of the powdered tablets containing 30  mg of Methylphenobarbital, mix with the aid of ultrasound for 10  minutes, add 50  ml of water, cool and dilute to 200  ml with methanol. Prepare solution (2) in the same manner as solution (1) but using 30  mg of methylphenobarbital BPCRS in place of the powdered tablets.


The chromatographic procedure described under the test for Related substances may be used.


Inject 10 µl of each solution. Calculate the content of C13H14N2O3 using the declared content of C13H14N2O3 in methylphenobarbital BPCRS.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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