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High Quality USP/EP/BP GMP DMF FDA Morphine Tablets CAS NO 57-27-2 Producer

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Price: $ 0.08 / Tablet
Quantity:
min order: 1 Tablet
View wholesale prices
  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ237
  • Dideu
  • 57-27-2
  • C17H19NO3
  • 200-320-2
  • China
  • Morphine Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Mobile:+86-15129568250; Whatsapp: +8615129568250

Morphine Tablets 

Action and use

Opioid receptor agonist; analgesic.

Definition

Morphine Tablets contain Morphine Sulphate.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of morphine sulphate, (C17H19NO3)2,H2SO4,5H2O

92.5  to 107.5% of the stated amount.
Identification

A.  Extract a quantity of the powdered tablets containing 20  mg of Morphine Sulphate with 5  ml of water, filter and add to the filtrate 0.05  ml of iron(iii) chloride solution R1. A blue colour is produced.


B.  Extract a quantity of the powdered tablets containing 10  mg of Morphine Sulphate with 10  ml of water, filter and to 5  ml of the filtrate add 0.15  ml of dilute potassium hexacyanoferrate(iii) solution and 0.05  ml of iron(iii) chloride solution R1. A bluish-green colour is produced immediately which changes rapidly to blue.


C.  The powdered tablets yield the reactions characteristic of sulphates, Appendix VI.

Tests

Dissolution

Comply with the requirements for Monographs of the British Pharmacopoeia in the dissolution test for tablets and capsules, Appendix XII B1, using Apparatus 2. Use as the medium 900  ml of phosphate buffer pH 6.5 and rotate the paddle at 50 revolutions per minute. Withdraw a sample of 10  ml of the medium and filter. Carry out the method for liquid chromatography, Appendix III D, using the following solutions. Solution (1) contains 0.001% w/v of morphine sulphate BPCRS in phosphate buffer pH 6.5. Solution (2) is the filtered dissolution medium, diluted with phosphate buffer pH 6.5, if necessary, to produce a solution containing about 0.001% w/v of Morphine Sulphate.


The chromatographic procedure may be carried out using (a) a stainless steel column (10  cm × 4.6  mm) packed with end-capped octadecylsilyl silica gel for chromatography (5 µm) (Spherisorb ODS 2 is suitable), (b) a mixture of 50  volumes of methanol and 50  volumes of 0.01m sodium heptanesulphonate in 0.1m acetic acid as the mobile phase with a flow rate of 2.0  ml per minute and (c) a detection wavelength of 211  nm.


Inject 50 µl of each solution. Calculate the total content of morphine sulphate, (C17H19NO3)2,H2SO4,5H2O, in the medium using the declared content of C17H19NO3 in morphine sulphate BPCRS. Each g of C17H19NO3 is equivalent to 1.330  g of (C17H19NO3)2,H2SO4,5H2O.


Related substances

Complies with the test described under Morphine Suppositories but using 50 µl of each of the following solutions. For solution (1) remove any coating from the tablets and shake a quantity of the powdered tablet cores containing 10  mg of Morphine Sulphate with 10  ml of a mixture of ethanol (96%) and water for 10  minutes and filter. For solution (2) dissolve 5  mg of codeine phosphate in 5  ml of solution (1) and dilute 1  volume of the resulting solution to 200  volumes with a mixture of equal volumes of ethanol (96%) and water. For solution (3) dilute 2  volumes of solution (2) to 5  volumes with a mixture of equal volumes of ethanol (96%) and water.


The test is not valid unless the chromatogram obtained with solution (2) shows two clearly separated spots. Disregard any spot with an Rf value of less than 0.1.

Assay

Weigh and powder 20  tablets. Shake a quantity of the powder containing 0.1  g of Morphine Sulphate with 25  ml of water and 5  ml of 1m sodium hydroxide, add 1  g of ammonium sulphate, shake to dissolve, add 20  ml of ethanol (96%) and extract with successive quantities of 40, 20, 20 and 20  ml of a mixture of 3  volumes of chloroform and 1  volume of ethanol (96%). Wash each extract with the same 5  ml of water, filter and evaporate the solvent. Dissolve the residue in 10  ml of 0.05m hydrochloric acid VS, boil, cool, add 15  ml of water and titrate the excess of acid with 0.05m sodium hydroxide VS using methyl red solution as indicator. Each ml of 0.05m hydrochloric acid VS is equivalent to 18.97  mg of (C17H19NO3)2,H2SO4,5H2O.

Storage

Morphine Tablets should be protected from light.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

2316

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.


Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


Dideu Industries Consist Of Five Industry Chains:


I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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