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High Quality USP/EP/BP GMP DMF FDA Naproxen Oral Suspension CAS NO 22204-53-1 Producer

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  • AZ590
  • Dideu
  • 22204-53-1
  • C14H14O3
  • 244-838-7
  • China
  • Oral Suspension
  • High quality
  • 99.0% Min
  • 99%-101%
  • Oral Suspension
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

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Naproxen Oral Suspension

Action and use

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Definition

Naproxen Oral Suspension is an aqueous suspension of Naproxen in a suitable flavoured vehicle.

The oral suspension complies with the requirements stated under Oral Liquids and with the following requirements.

Content of naproxen, C14H14O3 

90.0  to 110.0% of the stated amount.

Identification

Evaporate 50  ml of solution A obtained in the Assay to dryness using a rotary evaporator. The residue complies with the following tests.

A.  The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of naproxen (RS 244).

B.  The light absorption, Appendix II B, in the range 230  to 350  nm of a 0.004% w/v solution in methanol exhibits four maxima, at 262, 271, 316 and 331  nm.

Tests

Related substances

Tests

Acidity

pH, 2.1  to 4.0, Appendix V L.

Related substances

Carry out the method for thin-layer chromatography, Appendix III A, using silica gel GF254 as the coating substance and a mixture of 3  volumes of glacial acetic acid, 9  volumes of tetrahydrofuran and 90  volumes of toluene as the mobile phase. Apply separately to the plate 10 µl of each of the following solutions. For solution (1) evaporate solution A obtained in the Assay to dryness on a rotary evaporator and dissolve the residue in sufficient methanol to produce a solution containing 5.0% w/v of Naproxen. For solution (2) dilute 1  volume of solution (1) to 200  volumes with methanol. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%).

Assay

To a quantity of the oral suspension containing 0.5  g of Naproxen add 20  ml of 3.5m hydrochloric acid, mix, extract with three 50  ml quantities of chloroform, filter each extract through anhydrous sodium sulphate, combine the filtrates and add sufficient chloroform to produce 200  ml (solution A). To 5  ml of solution A add sufficient methanol to produce 250  ml and measure the absorbance of the resulting solution at the maximum at 331  nm, Appendix II B. Calculate the content of C14H14O3  taking 81.0 as the value of A(1%, 1  cm) at the maximum at 331  nm.




The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Oral Suspension 1Oral Suspension 15Oral Suspension 46

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Why do you choose Dideu Industries as your partner?


A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


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D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.


At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.


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I)Pharmaceutical Industries

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VI)General Chemical Industry


At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.


At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 


We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.


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