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High Quality USP/EP/BP GMP DMF FDA Phytomenadione Tablets CAS NO 84-80-0 Producer

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Price: $ 0.08 / Tablet
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  • AZ281
  • Dideu
  • 84-80-0
  • C31H46O2
  • 201-564-2
  • China
  • Phytomenadione Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Phytomenadione Tablets 

Action and use

Vitamin K analogue.


Phytomenadione Tablets contain Phytomenadione.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of phytomenadione, C31H46O2

90.0  to 110.0% of the stated amount.

Shake a quantity of the powdered tablets containing 50  mg of Phytomenadione with 50  ml of absolute ethanol for 1  hour, allow to stand and dilute 5  ml of the clear supernatant liquid to 50  ml with absolute ethanol. The light absorption of the resulting solution, Appendix II B, in the range 230  to 350  nm exhibits a maximum at 328  nm and a minimum at 292  nm. Dilute a suitable volume of the solution with sufficient absolute ethanol to produce a solution containing 0.001% w/v of Phytomenadione. The light absorption of this solution, in the range 230  to 350  nm, exhibits maxima at 245, 249, 263 and 271  nm and minima at 256  nm and 266  nm.


Related substances


The requirement for Disintegration does not apply to Phytomenadione Tablets.


Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using a TLC silica gel F254 plate (Merck silica gel 60 F254 plates are suitable) and a mixture of 1  volume of methanol, 20  volumes of ether and 80  volumes of cyclohexane as the mobile phase. Apply separately to the plate 50 µl of each of the following solutions. For solution (1) disperse a quantity of the powdered tablets containing 50  mg of Phytomenadione in 5  ml of absolute ethanol with the aid of ultrasound for 5  minutes, add 15  ml of 2,2,4-trimethylpentane, shake for 1  minute, centrifuge and use the supernatant liquid. Solution (2) contains 0.0025% w/v of menadione in 2,4,4-trimethylpentane. After removal of the plate, allow it to dry in air and examine under ultraviolet light (254  nm). Any secondary spot corresponding to menadione in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (1%).


Weigh and powder 20  tablets. Carry out in subdued light the method for liquid chromatography, Appendix III D, using the following solutions. Solution (1) contains 0.01% w/v of phytomenadione EPCRS in the mobile phase. For solution (2) add 5  ml of 0.5m ammonia to a quantity of the powdered tablets containing 10  mg of Phytomenadione and mix with the aid of ultrasound for 5  minutes. Add 90  ml of ethanol (96%) and mix with the aid of ultrasound for 10  minutes. Shake for 10  minutes, add sufficient ethanol (96%) to produce 100  ml, centrifuge and use the clear supernatant layer.

The chromatographic procedure may be carried out using (a) a stainless steel column (20  cm × 4  mm) packed with octadecylsilyl silica gel for chromatography (5 µm) (Spherisorb ODS 1 is suitable), (b) a mixture of 5  volumes of water and 95  volumes of ethanol (96%) as the mobile phase with a flow rate of 1.5  ml per minute and (c) a detection wavelength of 254  nm.

Calculate the content of C31H46O2 using the declared content of C31H46O2 in phytomenadione EPCRS.


The label states that the tablets should be chewed before swallowing or allowed to dissolve slowly in the mouth.

When vitamin K1  tablets are prescribed or demanded, Phytomenadione Tablets shall be dispensed or supplied.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

II)Nutrition Additive Industries

III)Daily-Use Chemical Products Industries & Agrochemicals

IV)Environmental Friendly Chemical And Chemurgy Industries

V)Petrochemical Industries

VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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