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High Quality USP/EP/BP GMP DMF FDA Pyridostigmine Tablets CAS NO Producer

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Price: $ 0.08 / Tablet
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  • Quantity Price
  • 1 $0.5
  • 10000 $0.2
  • 100000 $0.1
  • 300000 $0.08
  • AZ325
  • Dideu
  • China
  • Pyridostigmine Tablets
  • High quality
  • 99.0% Min
  • 99%-101%
  • Tablet
  • Solubility in water
  • 1.0% max
  • 0.5% Max
  • 10 ppm Max
  • H-NMR
  • 0.5% Max
  • Medicine

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

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Pyridostigmine Tablets 

Action and use

Cholinesterase inhibitor.


Pyridostigmine Tablets contain Pyridostigmine Bromide.

The tablets comply with the requirements stated under Tablets and with the following requirements.

Content of pyridostigmine bromide, C9H13BrN2O2

92.5  to 107.5% of the stated amount.

A.  Triturate a quantity of the powdered tablets containing 0.1  g of Pyridostigmine Bromide with two 5  ml quantities of water and filter. Dilute the filtrate with water to contain 0.005% w/v of Pyridostigmine Bromide. The light absorption of the resulting solution, Appendix II B, exhibits a maximum at 270  nm. Reserve the filtrate for use in tests B and C.

B.  Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions.

(1)  dilute 1  volume of the filtrate obtained in test A to 10  volumes with methanol.

(2)  0.1% w/v of pyridostigmine bromide EPCRS in methanol.

chromatographic conditions

(a)  Use as the coating silica gel G.

(b)  Use the mobile phase as described below. 

(c)  Apply 10 µl of each solution.

(d)  Develop the plate to 20 cm.

(e)  After removal of the plate, dry in air, spray with dilute potassium iodobismuthate solution.

mobile phase

A mixture of 5  volumes of water, 10  volumes of formic acid, 35  volumes of methanol and 50  volumes of chloroform.


The principal spot in the chromatogram obtained with solution (1) corresponds to that in the chromatogram obtained with solution (2).

C.  The filtrate obtained in test A yields the reactions characteristic of bromides, Appendix VI.


Related substances

Carry out the method for liquid chromatography, Appendix III D, using the following solutions.

(1)  Shake a quantity of powdered tablets containing 0.1  g of Pyridostigmine Bromide with 100  ml of a mixture of 30  volumes of acetonitrile and 70  volumes of water for 30  minutes and filter through a glass fibre filter (Whatman GF/C is suitable)

(2)  Dilute 6  volumes of solution (1) to 100  volumes with a mixture of 30  volumes of acetonitrile and 70  volumes of water.

(3)  Dilute 1  volume of solution (1) to 250  volumes with a mixture of 30  volumes of acetonitrile and 70  volumes of water.

(4)  0.0005% w/v each of pyridostigmine impurity A EPCRS and pyridostigmine bromide EPCRS in the mobile phase.

(5)  Dilute 1  volume of solution (3) to 10  volumes with a mixture of 30  volumes of acetonitrile and 70  volumes of water.

chromatographic conditions 

(a)  Use a stainless steel column (25  cm × 4.6  mm) packed with base-deactivated octadecylsilyl silica gel for chromatography (5 µm) (Hypersil BDS C18 is suitable).

(b)  Use isocratic elution and the mobile phase described below.

(c)  Use a flow rate of 1.1  ml per minute.

(d)  Use an ambient column temperature.

(e)  Use a detection wavelength of 220 nm.

(f)  Inject 20 µl of each solution. 

(g)  Allow the chromatography to continue for at least twice the retention time of the peak due to Pyridostigmine.

mobile phase

30  volumes of acetonitrile and 70  volumes of a 0.43% w/v solution of sodium dodecyl sulphate, previously adjusted to pH 2.0 with orthophosphoric acid.

system suitability 

The test is not valid unless, in the chromatogram obtained with solution (4), the resolution factor between the peaks corresponding to pyridostigmine impurity A and pyridostigmine bromide is at least 1.5.


In the chromatogram obtained with solution (1):

the area of any peak corresponding to pyridostigmine impurity B is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (6%);

the area of any peak corresponding to impurity pyridostigmine impurity A is not greater than the area of the principal peak in the chromatogram obtained with solution (3) (0.4%);

the sum of the areas of any other secondary peaks is not greater than the principal peak in the chromatogram obtained with solution (3) (0.4%).

Disregard any peak with an area less than the area of the principal peak in the chromatogram obtained with solution (5) (0.04%).


Weigh and powder 20  tablets. Shake a quantity of the powdered tablets containing 0.15  g of Pyridostigmine Bromide with 50  ml of water for 30  minutes, filter, wash the residue with water and add sufficient water to produce 250  ml. Dilute 5  ml to 100  ml with water and measure the absorbance of the resulting solution at the maximum at 270  nm, Appendix II B. Calculate the content of C9H13BrN2O2  taking 186 as the value of A(1%, 1  cm) at the maximum at 270  nm.


Pyridostigmine Tablets should be protected from light.


The impurities limited by the requirements of this monograph include impurities A and B listed under Pyridostigmine Bromide.

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries

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At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power. 

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

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